Caffeic acid phenethyl ester

Cat. No. 2743 11 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Specific inhibitor of NF-κB activation

别名： CAPE

化学名： 3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester

纯度： ≥98% (HPLC)

引用文献 (11)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Caffeic acid phenethyl ester

Caffeic acid phenethyl ester is an antioxidant, antimitogenic, anticarcinogenic, anti-inflammatory and antiviral. Specifically inhibits NF-κB activation and inhibits the growth of transformed cells. Also suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities.

技术数据 for Caffeic acid phenethyl ester

分子量	284.31
公式	C₁₇H₁₆O₄
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	104594-70-9
PubChem ID	5281787
InChI Key	SWUARLUWKZWEBQ-VQHVLOKHSA-N
Smiles	OC1=C(O)C=C(/C=C/C(OCCC2=CC=CC=C2)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Caffeic acid phenethyl ester

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	28.43	100
	ethanol	28.43	100

制备储备液 for Caffeic acid phenethyl ester

以下数据基于产品分子量 284.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.52 mL	17.59 mL	35.17 mL
5 mM	0.7 mL	3.52 mL	7.03 mL
10 mM	0.35 mL	1.76 mL	3.52 mL
50 mM	0.07 mL	0.35 mL	0.7 mL

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产品说明书 for Caffeic acid phenethyl ester

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Caffeic acid phenethyl ester

参考文献是支持产品生物活性的出版物。

Sud'ina et al (1993) Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett. 329 21 PMID: 7689063

Fitzpatrick et al (2001) Caffeic acid phenethyl ester, an inhibitor of nuclear factor-κB, attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats. J.Pharmacol.Exp.Ther. 299 915 PMID: 11714876

Natarajan et al (1996) Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-κB. Proc.Natl.Acad.Sci.USA 93 9090

If you know of a relevant reference for Caffeic acid phenethyl ester, please let us know.

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关键词: Caffeic acid phenethyl ester, Caffeic acid phenethyl ester supplier, Specific, inhibitors, inhibits, NF-κB, NF-kappaB, NF-kB, activation, Transcription, Factors, Nuclear, Factor, Kappa, B, Cytokine, Signaling, Signalling, CAPE, NF-kB/IkB, Non-selective, Antivirals, 2743, Tocris Bioscience

11 篇 Caffeic acid phenethyl ester 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Caffeic acid phenethyl ester 的部分引用包括：

Messerschmidt et al (2019) Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation. Mol Vis 25 329 PMID: 31341381

Mia and Bank (2016) The pro-fibrotic properties of transforming growth factor on human fibroblasts are counteracted by caffeic acid by inhibiting myofibroblast formation and collagen synthesis. PLoS Pathog 363 775 PMID: 26453399

Ong et al (2015) Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis. Mol Vis 11 e1004917 PMID: 25996154

Brosig et al (2015) Gene expression regulation in retinal pigment epithelial cells induced by viral RNA and viral/bacterial DNA. Mol Vis 21 1000 PMID: 26330750

Hollborn et al (2015) Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5. Cell Biosci 21 360 PMID: 25878490

Pysz et al (2014) Differential regulation of cyclin D1 expression by protein kinase C α and ε signaling in intestinal epithelial cells. J Biol Chem 289 22268 PMID: 24914206

Zhu et al (2012) BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. Front Cell Neurosci 31 31 PMID: 22463935

Munegowda and Hu (2015) Transient blocking of NK cell function with small molecule inhibitors for helper dependant adenoviral vector-mediated gene delivery. J Exp Clin Cancer Res 5 29 PMID: 26085921

Kleiner et al (2018) Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells. Mol Vis 24 647 PMID: 30310263

Tawara et al (2019) HIGH expression of OSM and IL-6 are associated with decreased breast cancer survival: synergistic induction of IL-6 secretion by OSM and IL-1β. Oncotarget 10 2068 PMID: 31007849

Ciarlo et al (2017) A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development. Elife 6 PMID: 28832322

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