Calhex 231 hydrochloride

Cat. No. 4387 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Negative allosteric modulator of calcium-sensing receptor (CaSR)

化学名： 4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride

纯度： ≥98% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Calhex 231 hydrochloride

Calhex 231 hydrochloride is a negative allosteric modulator of the calcium sensing receptor (CaSR). Blocks increases in [³H]inositol phosphate levels elicited by wild-type hCasR activation (IC₅₀= 0.39 μM in transiently transfected HEK293 cells).

化合物库 for Calhex 231 hydrochloride

Calhex 231 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Calhex 231 hydrochloride

分子量	443.41
公式	C₂₅H₂₇ClN₂O.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2387505-78-2
PubChem ID	11849513
InChI Key	KZPHZSFSFANQIS-GRFVZBLOSA-N
Smiles	O=C(C4=CC=C(Cl)C=C4)N[C@@H](CCCC3)[C@H]3N[C@H](C)C1=C2C(C=CC=C2)=CC=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Calhex 231 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	22.17	50

制备储备液 for Calhex 231 hydrochloride

以下数据基于产品分子量 443.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	4.51 mL	22.55 mL	45.1 mL
2.5 mM	0.9 mL	4.51 mL	9.02 mL
5 mM	0.45 mL	2.26 mL	4.51 mL
25 mM	0.09 mL	0.45 mL	0.9 mL

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产品说明书 for Calhex 231 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Calhex 231 hydrochloride

参考文献是支持产品生物活性的出版物。

Petrel et al (2003) Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca²⁺-sensing receptor. J.Biol.Chem. 278 49487 PMID: 14506236

Kessler et al (2006) N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (Calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity. J.Med.Chem. 49 5119 PMID: 16913701

Weston et al (2008) The expression and function of Ca²⁺-sensing receptors in rat mesenteric artery; comparative studies using a model of type II diabetes. Br.J.Pharmacol. 154 652 PMID: 18414396

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