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Submit ReviewCaptopril
说明： ACE inhibitor; also inhibits LTA4 hydrolase
化学名： 1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-L-proline
纯度： ≥98% (HPLC)
生物活性 for Captopril
Captopril is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.022 μM). Also displays reversible, competitive inhibition of leukotriene A4 (LTA4) hydrolase. Identified as targeting human host proteins that interact with SARS-CoV-2.
技术数据 for Captopril
| 分子量 | 217.29 |
| 公式 | C9H15NO3S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 62571-86-2 |
| PubChem ID | 44093 |
| InChI Key | FAKRSMQSSFJEIM-RQJHMYQMSA-N |
| Smiles | O=C([C@H](C)CS)N1[C@H](C(O)=O)CCC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Captopril
参考文献 for Captopril
参考文献是支持产品生物活性的出版物。
Zhang et al (1996) Effects of early capt. treatment and its removal on plasma angiotensin converting enzyme (ACE) activity and arginine vasopressin in hypertensive rats (SHR) and normotensive rats (WKY). Clin.Exp.Hypertens. 18 201 PMID: 8869001
Orning et al (1991) Inhibition of leukotriene A4 hydrolase/aminopeptidase by capt. J.Biol.Chem. 266 16507 PMID: 1885582
Fujita and Yoshikawa (1999) LKPNM: a prodrug-type ACE-inhibitory peptide derived from fish protein. Immunopharmacology. 44 123 PMID: 10604535
Gordon et al A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature 583 PMID: 32353859
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关键词: Captopril, Captopril supplier, ACE, inhibitors, angiotensin-converting, enzyme, antihypertensives, LTA4, reversible, inhibits, peptidyl, dipeptidase, A, carboxycathepsin, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, Angiotensin-Converting, Enzyme, Aminopeptidases, Hydrolase, 4455, Tocris Bioscience
1 篇 Captopril 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Captopril 的部分引用包括：
Gupta et al (2014) Opioid receptor function is regulated by post-endocytic peptide processing. J Biol Chem 289 19613 PMID: 24847082
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