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Submit ReviewCarbamazepine is an inhibitor of neuronal voltage-gated Na+ channels. Exhibits anticonvulsant activity. Potentiates GABA-induced Cl- currents in HEK 293 cells expressing the GABAA receptor α1β2γ2 subtype combination. Can induce autophagy by inhibiting inositol synthesis. Also delays disease onset and prolongs survival in a mouse amyotrophic lateral sclerosis (ALS) model, as well as reducing motor neuron loss and altered muscle morphology.
Carbamazepine is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
分子量 | 236.27 |
公式 | C15H12N2O |
储存 | Store at +4°C |
纯度 | ≥98% (HPLC) |
CAS Number | 298-46-4 |
PubChem ID | 2554 |
InChI Key | FFGPTBGBLSHEPO-UHFFFAOYSA-N |
Smiles | NC(N1C3=C(C=CC=C3)C=CC2=C1C=CC=C2)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 23.63 | 100 | |
ethanol | 5.91 | 25 |
以下数据基于产品分子量 236.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 4.23 mL | 21.16 mL | 42.32 mL |
5 mM | 0.85 mL | 4.23 mL | 8.46 mL |
10 mM | 0.42 mL | 2.12 mL | 4.23 mL |
50 mM | 0.08 mL | 0.42 mL | 0.85 mL |
参考文献是支持产品生物活性的出版物。
Granger et al (1995) Modulation of the gamma-aminobutyric acid type A receptor by the antiepileptic drugs carbamaz. and phen. Mol.Pharmacol. 47 1189 PMID: 7603459
Afanas'ev et al (1999) Lamotrigine and carbamaz. affect differently the release of D-[3H] aspartate from mouse cerebral cortex slices: involvement of NO. Neurochem.Res. 24 1153 PMID: 10485587
Lipkind and Fozzard (2010) Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore. Mol.Pharmacol. 78 631 PMID: 20643904
Sarkar et al (2009) Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ. 16 46 PMID: 18636076
Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. 16 487 PMID: 28529316
Zhang et al (2018) Repurposing carbamaz. for the treatment of amyotrophic lateral sclerosis in SOD1-G93A mouse model. CNS Neurosci.Ther. 24 1163 PMID: 29656576
If you know of a relevant reference for Carbamazepine, please let us know.
关键词: Carbamazepine, Carbamazepine supplier, sodium, Na+, channels, GABAA, ligands, inhibits, inhibitors, anticonvulsants, CBZ, Voltage-gated, Sodium, Channels, Autophagy, 4098, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 Carbamazepine 的部分引用包括:
Jing et al (2021) Cerebellar spreading depolarization mediates paroxysmal movement disorder. Cell Rep 36 109743 PMID: 34551285
Gábor et al (2017) Mechanisms for Selective Single-Cell Reactivation during Offline Sharp-Wave Ripples and Their Distortion by Fast Ripples. Neuron 94 1234-1247.e7 PMID: 28641116
Eero et al (2022) Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro. Front Pharmacol 12 755600 PMID: 35126106
Hui et al (2022) Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate. Mol Cell 82 2401-2414.e9 PMID: 35597236
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Carbamazepine's effect on serotonin systems observed and an attempt to explain how it exert it's antiseizure effects was made.
There is evidence that it is a serotonin releasing agent and possibly even a serotonin reuptake inhibitor