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Carbamazepine

Cat. No. 4098 4 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Inhibitor of neuronal NaV channels; anticonvulsant
别名： CBZ
化学名： 5H-Dibenz[b,f]azepine-5-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Carbamazepine

Carbamazepine is an inhibitor of neuronal voltage-gated Na+ channels. Exhibits anticonvulsant activity. Potentiates GABA-induced Cl- currents in HEK 293 cells expressing the GABAA receptor α1β2γ2 subtype combination. Can induce autophagy by inhibiting inositol synthesis. Also delays disease onset and prolongs survival in a mouse amyotrophic lateral sclerosis (ALS) model, as well as reducing motor neuron loss and altered muscle morphology.

化合物库 for Carbamazepine

Carbamazepine is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Carbamazepine

分子量 236.27
公式 C15H12N2O
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 298-46-4
PubChem ID 2554
InChI Key FFGPTBGBLSHEPO-UHFFFAOYSA-N
Smiles NC(N1C3=C(C=CC=C3)C=CC2=C1C=CC=C2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Carbamazepine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 23.63 100
ethanol 5.91 25

制备储备液 for Carbamazepine

以下数据基于产品分子量 236.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.23 mL 21.16 mL 42.32 mL
5 mM 0.85 mL 4.23 mL 8.46 mL
10 mM 0.42 mL 2.12 mL 4.23 mL
50 mM 0.08 mL 0.42 mL 0.85 mL

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产品说明书 for Carbamazepine

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Carbamazepine

参考文献是支持产品生物活性的出版物。

Granger et al (1995) Modulation of the gamma-aminobutyric acid type A receptor by the antiepileptic drugs carbamaz. and phen. Mol.Pharmacol. 47 1189 PMID: 7603459

Afanas'ev et al (1999) Lamotrigine and carbamaz. affect differently the release of D-[3H] aspartate from mouse cerebral cortex slices: involvement of NO. Neurochem.Res. 24 1153 PMID: 10485587

Lipkind and Fozzard (2010) Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore. Mol.Pharmacol. 78 631 PMID: 20643904

Sarkar et al (2009) Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ. 16 46 PMID: 18636076

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. 16 487 PMID: 28529316

Zhang et al (2018) Repurposing carbamaz. for the treatment of amyotrophic lateral sclerosis in SOD1-G93A mouse model. CNS Neurosci.Ther. 24 1163 PMID: 29656576

If you know of a relevant reference for Carbamazepine, please let us know.

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关键词: Carbamazepine, Carbamazepine supplier, sodium, Na+, channels, GABAA, ligands, inhibits, inhibitors, anticonvulsants, CBZ, Voltage-gated, Sodium, Channels, Autophagy, 4098, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Carbamazepine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

4 篇 Carbamazepine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Carbamazepine 的部分引用包括：

Eero et al (2022) Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro. Front Pharmacol 12 755600 PMID: 35126106

Hui et al (2022) Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate. Mol Cell 82 2401-2414.e9 PMID: 35597236

Jing et al (2021) Cerebellar spreading depolarization mediates paroxysmal movement disorder. Cell Rep 36 109743 PMID: 34551285

Gábor et al (2017) Mechanisms for Selective Single-Cell Reactivation during Offline Sharp-Wave Ripples and Their Distortion by Fast Ripples. Neuron 94 1234-1247.e7 PMID: 28641116

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Carbamazepine 的评论

平均评分: 5 (Based on 1 Review.)

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Carbamazepine's effect on serotonin systems observed.
By Anonymous on 01/16/2020
种属： Human

Carbamazepine's effect on serotonin systems observed and an attempt to explain how it exert it's antiseizure effects was made.

There is evidence that it is a serotonin releasing agent and possibly even a serotonin reuptake inhibitor

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