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Cariporide

Cat. No. 5358 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective NHE1 inhibitor; cardioprotective and antitumor
别名： HOE 642
化学名： N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Cariporide

Cariporide is a selective Na+/H+ exchanger isoform 1 (NHE1) inhibitor (IC50 values are 0.05, 3 and 1000 μM for NHE1, NHE3 and NHE2 respectively). Attenuates ischemia-induced cardiomyocyte apoptosis in vitro. Reduces cardiac arrhythmia in vivo. Also promotes apoptosis in cancer cells overexpressing NHE1. Orally active.

化合物库 for Cariporide

Cariporide is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Cariporide

分子量 283.35
公式 C12H17N3O3S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 159138-80-4
PubChem ID 151172
InChI Key IWXNYAIICFKCTM-UHFFFAOYSA-N
Smiles CC(C)C1=C(S(C)(=O)=O)C=C(C(NC(N)=N)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cariporide

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 28.34 100

制备储备液 for Cariporide

以下数据基于产品分子量 283.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.53 mL 17.65 mL 35.29 mL
5 mM 0.71 mL 3.53 mL 7.06 mL
10 mM 0.35 mL 1.76 mL 3.53 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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产品说明书 for Cariporide

分析证书/产品说明书
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关键词: Cariporide, Cariporide supplier, Cariporide, HOE642, selective, sodium, hydrogen, exchanger, NHE1, inhibitors, inhibits, cardioprotective, cardiomyocytes, ischemia, orally, active, Na+/H+, HOE, 642, Exchanger, 5358, Tocris Bioscience

1 篇 Cariporide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Cariporide 的部分引用包括：

Alzbeta et al (2022) Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes. Elife 11 PMID: 36107487

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