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CBM 301940

Cat. No. 6319 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent malonyl-CoA decarboxylase inhibitor; orally bioavailable
化学名： tert-Butyl 3-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamido)butanoate
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CBM 301940

CBM 301940 is a potent malonyl-CoA decarboxylase (MCD) inhibitor (IC50 = 23 nM). Suppresses malonyl-CoA degradation and fatty acid oxidation in isolated rat hearts, leading to secondary increase in glucose oxidation. Improves cardiac function during reperfusion of ischemic isolated rat hearts. Orally bioavailable.

化合物库 for CBM 301940

CBM 301940 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CBM 301940

分子量 422.32
公式 C15H20F6N2O5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 902146-11-6
PubChem ID 10387489
InChI Key SBPVPWWNQIKSKL-UHFFFAOYSA-N
Smiles CC(NC(C1=NOC(C(C(F)(F)F)(C(F)(F)F)O)C1)=O)CC(OC(C)(C)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CBM 301940

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 42.23 100
ethanol 42.23 100

制备储备液 for CBM 301940

以下数据基于产品分子量 422.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.84 mL 23.68 mL
5 mM 0.47 mL 2.37 mL 4.74 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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参考文献 for CBM 301940

参考文献是支持产品生物活性的出版物。

Dyck et al (2004) Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circ.Res. 94 e78 PMID: 15105298

Cheng et al (2006) Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. J.Med.Chem. 49 4055 PMID: 16821767

If you know of a relevant reference for CBM 301940, please let us know.

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关键词: CBM 301940, CBM 301940 supplier, CBM301940, MCD, malonyl, coenzyme, A, CoA, inhibitors, inhibits, potent, orally, bioavailable, Decarboxylases, Other, Lipid, Metabolism, 6319, Tocris Bioscience

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