CCG 1423

Name: CCG 1423
Brand: Tocris Bioscience
SKU: 5233

Cat. No. 5233 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5233 has been discontinued.

View all Rho GTPases products.

说明： Rho/SRF pathway inhibitor; induces intermediate mesoderm differentiation from ESCs

化学名： N-[2-[(4-Chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)benzamide

纯度： ≥99% (HPLC)

说明书

引用文献 (4)

生物活性技术数据说明书参考文献

生物活性 for CCG 1423

CCG 1423 is a Rho/SRF pathway inhibitor; stimulates apoptosis of a melanoma cell line overexpressing RhoC (A375M2). Suppresses Rho-dependent invasion of PC-3 prostate cancer cells in vitro and inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells. When used in combination with Retinoic acid, LY 294002 and Pyridone 6, it induces intermediate mesoderm differentiation from ESCs.

化合物库 for CCG 1423

CCG 1423 is also offered as part of the Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for CCG 1423

分子量	454.75
公式	C₁₈H₁₃ClF₆N₂O₃
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	285986-88-1
PubChem ID	2726015
InChI Key	DSMXVSGJIDFLKP-UHFFFAOYSA-N
Smiles	O=C(NOC(C)C(NC2=CC=C(Cl)C=C2)=O)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for CCG 1423

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CCG 1423

参考文献是支持产品生物活性的出版物。

Mae et al (2010) Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. Biochem.Biophys.Res.Commun. 393 877 PMID: 20171952

Evelyn et al (2007) CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. Mol.Cancer Ther. 6 2249 PMID: 17699722

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