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Ceapin A7

Cat. No. 6955 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective inhibitor of ATF6α; sensitizes cells to ER stress
化学名： N-[1-[[2,4-bis(Trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)-3-isoxazolecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ceapin A7

Ceapin A7 is a selective inhibitor of ATF6α (IC50=0.59 μM). The compound selectively inhibits ATF6α over ATF6β and other branches of the unfolded protein response (UPR). Ceapin A7 inhibits ER stress-induced upregulation of BiP in vitro. Ceapin A7 inhibits cleavage and functional activation of endogenous ATF6 in response to ER stress in vitro.

技术数据 for Ceapin A7

分子量 470.33
公式 C20H12F6N4O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2323027-38-7
PubChem ID 154730128
InChI Key UJTDYOXTXGBHEG-UHFFFAOYSA-N
Smiles FC(F)(C1=CC(C(F)(F)F)=C(C=C1)CN2C=C(C=N2)NC(C3=NOC(C4=CC=CO4)=C3)=O)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ceapin A7

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 47.03 100
ethanol 4.7 10

制备储备液 for Ceapin A7

以下数据基于产品分子量 470.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.63 mL 21.26 mL
5 mM 0.43 mL 2.13 mL 4.25 mL
10 mM 0.21 mL 1.06 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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参考文献 for Ceapin A7

参考文献是支持产品生物活性的出版物。

Gallagher et al (2016) Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6a branch. eLife PMID: 27435960

Gallagher and Walter (2016) Ceapins inhibit ATF6a signaling by selectively preventing transport of ATF6a to the Golgi apparatus during ER stress. eLife PMID: 27435962

If you know of a relevant reference for Ceapin A7, please let us know.

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关键词: Ceapin A7, Ceapin A7 supplier, Ceapin, A7, inhibitors, inhibit, inhibition, ATF6, ER, stress, unfolded, protein, response, UPR, Other, stress/UPR, Transcription, Factors, 6955, Tocris Bioscience

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