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Celastrol

Cat. No. 3203 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibits TNF-α-induced NF-κB activation
化学名： (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Celastrol

Celastrol is an antioxidant, anti-inflammatory, antitumor and neuroprotective agent. Inhibits lipid peroxidation in mitochondria, TNF-α-induced NFκB activation, peroxidase activity of peroxiredoxin 1 (IC50 = 0.29 μM), and topoisomerase II activity in vitro (IC50 = 7.41 μM). Celastrol treatment inhibits the growth of PC-3 tumors in mice.

技术数据 for Celastrol

分子量 450.61
公式 C29H38O4
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 34157-83-0
PubChem ID 122724
InChI Key KQJSQWZMSAGSHN-JJWQIEBTSA-N
Smiles O=C2C(O)=C(C)C1=CC=C([C@](CC[C@]5(C)[C@]([H])4C[C@](C)([C@@](O)=O)CC5)(C)[C@@]4(C)CC3)[C@]3(C)C1=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Celastrol

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 45.06 100
ethanol 33.8 75

制备储备液 for Celastrol

以下数据基于产品分子量 450.61。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.1 mL 22.19 mL
5 mM 0.44 mL 2.22 mL 4.44 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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产品说明书 for Celastrol

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Celastrol

参考文献是支持产品生物活性的出版物。

Nagase et al (2003) Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol. Biosci.Biotechnol.Biochem. 67 1883 PMID: 14519971

Sethi et al (2007) Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB-regulated gene products and TAK1-mediated NF-κB activation. Blood 109 2727 PMID: 17110449

Sassa et al (1990) The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Biochem.Biophys.Res.Comms. 172 890 PMID: 2241977

Xu et al (2023) Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. Signal Transduct.Target Ther. 8 51 PMID: 36732502

Yang et al (2006) Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 66 4758 PMID: 16651429

If you know of a relevant reference for Celastrol, please let us know.

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关键词: Celastrol, Celastrol supplier, inhibitors, inhibits, TNF-α, TNF-alpha-induced, NF-κB, NF-kappaB, NF-kB, activation, Antioxidant, anti-inflammatory, Topoisomerase, II, Nuclear, Factor, Kappa, B, Cytokine, Signaling, Signalling, Transcription, Factors, DNA, Isomerases, tripterine, tripterin, Antioxidants, NF-kB/IkB, 3203, Tocris Bioscience

1 篇 Celastrol 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Celastrol 的部分引用包括：

Zwicker et al (2015) Interleukin 34: a new modulator of human and experimental inflammatory bowel disease. Clin Sci (Lond) 129 281 PMID: 25896238

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Pathways for Celastrol

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.