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Submit ReviewCelecoxib
说明： Selective cyclooxygenase-2 (COX-2) inhibitor
别名： SC 58635,Celebrex
化学名： 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide
纯度： ≥99% (HPLC)
生物活性 for Celecoxib
Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively). Celecoxib is an anti-inflammatory with shorter plasma half-life in vivo than SC 58121. Displays chemopreventive activity in in vivo tumor models.
化合物库 for Celecoxib
Celecoxib is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for Celecoxib
| 分子量 | 381.37 |
| 公式 | C17H14F3N3O2S |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 169590-42-5 |
| PubChem ID | 2662 |
| InChI Key | RZEKVGVHFLEQIL-UHFFFAOYSA-N |
| Smiles | CC(C=C3)=CC=C3C1=CC(C(F)(F)F)=NN1C2=CC=C(S(=O)(N)=O)C=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Celecoxib
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 9.53 | 25 | |
| ethanol | 19.07 | 50 |
制备储备液 for Celecoxib
以下数据基于产品分子量 381.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.24 mL | 26.22 mL | 52.44 mL |
| 2.5 mM | 1.05 mL | 5.24 mL | 10.49 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.24 mL |
| 25 mM | 0.1 mL | 0.52 mL | 1.05 mL |
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产品说明书 for Celecoxib
参考文献 for Celecoxib
参考文献是支持产品生物活性的出版物。
Penning et al (1997) Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). J.Med.Chem. 40 1347 PMID: 9135032
DeWitt (1999) Cox-2-selective Inhibitors: the new super aspirins. Mol.Pharmacol. 55 625 PMID: 10101019
Harris et al (2000) Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor. Cancer Res. 60 2101 PMID: 10786667
If you know of a relevant reference for Celecoxib, please let us know.
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关键词: Celecoxib, Celecoxib supplier, Selective, cyclooxygenase-2, COX-2, inhibitors, inhibits, Oxygenases, Oxidases, SC58635, prostaglandins, SC, 58635, Celebrex, Cyclooxygenase, 3786, Tocris Bioscience
4 篇 Celecoxib 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Celecoxib 的部分引用包括：
Christopher J et al (2022) Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer Res 82 3375-3393 PMID: 35819261
Cesare et al (2020) Celecoxib Exerts Neuroprotective Effects in β-Amyloid-Treated SH-SY5Y Cells Through the Regulation of Heme Oxygenase-1: Novel Insights for an Old Drug. Front Cell Dev Biol 8 561179 PMID: 33134292
Bowler et al (2019) CXB Is Associated With Dystrophic Calcification and Aortic Valve Stenosis. JACC Basic Transl Sci 4 135 PMID: 31061914
Oguh-Olayinka et al (2019) The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma. Pathol Oncol Res PMID: 30941737
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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