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说明： Selective hα1A adrenergic receptor fluorescent antagonist
纯度： ≥95% (HPLC)
生物活性 for CELT-133
CELT-133 is a selective hα1A adrenergic receptor fluorescent antagonist. It shows full selectivity for α1A over α2A (Ki= 5 nM and 15% of displacement at 1 μM respectively in radioligand binding assay). CELT-133 binds equally to all subtypes of α1 adrenergic receptor. Excitation and emission maxima (λ) are 560 and 571 nm, respectively. Wavelengths are compatible with use as an acceptor dye in TR-FRET assays, together with the CoraFluor™ 1 (Cat. No. 7920) TR-FRET donor.
Add 76 μL of assay buffer containing 1% of DMSO to obtain a 100 μM stock solution, and use 250 nM as a working concentration.
许可信息
Sold under license from Celtarys Research
Optical Data for CELT-133
| Emission Color | Yellow |
|---|---|
| λabs | 560 nm |
| λem | 571 nm |
| Application | Fluorescence polarization, Confocal microscopy, High content screening |
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技术数据 for CELT-133
| 分子量 | 1318.43 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CELT-133
参考文献 for CELT-133
参考文献是支持产品生物活性的出版物。
Kenny et al (1996) Evaluation of the pharmacological selectivity profile of alpha 1 adrenoceptor antagonists at prostatic alpha 1 adrenoceptors: binding, functional and in vivo studies. Br.J.Pharmacol. 118 871 PMID: 8799556
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关键词: CELT-133, CELT-133 supplier, adrenergic, alpha1A, receptor, ligand, fluorescent, probe, fluorescence, TR-FRET, assay, Fluorescent, Receptor, Probes, and, FP, Assay, Reagents, Adrenergic, Alpha-1, Receptors, 7952, Tocris Bioscience
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Fluorescent Dyes and Probes Research Product Guide
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