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Cerulenin

Cat. No. 6702 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6702 has been discontinued.

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说明： Irreversible fatty acid synthase inhibitor
化学名： (2R,3S)-3-[(4E,7E)-1-Oxo-4,7-nonadien-1-yl]-2-oxiranecarboxamide
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生物活性 技术数据 说明书 参考文献

生物活性 for Cerulenin

Cerulenin is an irreversible fatty acid synthase inhibitor. Blocks proliferation of KRAS-driven lung cancer cells. Promotes apoptosis and inhibits necroptosis in cancer cells. Also inhibits protein palmitoylation and insulin uptake in rat adipocytes in vitro. Antibiotic.

技术数据 for Cerulenin

分子量 223.27
公式 C12H17NO3
储存 Store at -20°C
CAS Number 17397-89-6
PubChem ID 5282054
InChI Key GVEZIHKRYBHEFX-NQQPLRFYSA-N
Smiles C/C=C/C/C=C/CCC([C@H]1O[C@H]1C(N)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Cerulenin

参考文献是支持产品生物活性的出版物。

Gouw et al (2017) Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma. Proc.Natl.Acad.Sci.U.S.A. 114 4300 PMID: 28400509

Parisi et al (2017) Very long chain fatty acids are functionally involved in necroptosis. Cell Chem.Bio. 24 1445 PMID: 29033315

Jochen et al (1995) Inhibitory effects of cerulenin on protein palmitoylation and Ins internalization in rat adipocytes. Biochim.Biophys.Acta. 1259 65 PMID: 7492617

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关键词: Cerulenin, Cerulenin supplier, fatty, acid, synthase, FASN, inhibitor, inhibits, irreversible, Fatty, Acid, Synthase, Antibiotics, 6702, Tocris Bioscience

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