Cetrorelix Acetate

Name: Cetrorelix Acetate
Brand: Tocris Bioscience
SKU: 3536

Cat. No. 3536 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

This product has been withdrawn from sale and is superseded by Cetrorelix acetate (Cat. No. 8821)

说明： Potent GnRH receptor antagonist

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for Cetrorelix Acetate

Cetrorelix Acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist (K_D = 0.202 nM, IC₅₀ = 1.21 nM). Suppresses production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, which inhibits ovulation. Exhibits antiproliferative effects and displays efficacy against hormone-sensitive cancers in vivo. Also exhibits anxiolytic and antidepressant activity in vivo.

技术数据 for Cetrorelix Acetate

分子量	1491.11
公式	C₇₀H₉₂ClN₁₇O₁₄.C₂H₄O₂
序列	XFASYXLRPA (Modifications: X-1 = D-2-Nal and N-terminal Ac, Phe-2 = D-(4-Cl-Phe), Ala-3 = D-(3-Pyridyl-Ala), X-6 = D-Cit, Ala-10 = D-Ala and C-terminal amide)
储存	Store at -20°C
CAS Number	145672-81-7
PubChem ID	25078429
InChI Key	KFEFLCOCAHJBEA-ANRVCLKPSA-N
Smiles	CC(O)=O.CC(C)C[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC1=CN=CC=C1)NC(=O)[C@@H](CC1=CC=C(Cl)C=C1)NC(=O)[C@@H](CC1=CC2=C(C=CC=C2)C=C1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Cetrorelix Acetate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Cetrorelix Acetate

参考文献是支持产品生物活性的出版物。

Beckers et al (1997) Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal.Biochem. 251 17 PMID: 9300077

Grundker and Emons (2003) Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod.Biol.Endocrinol. 1 65 PMID: 14594454

Telegdy et al (2009) Effects of the LHRH antagonist cetro. on the brain function in mice. Neuropeptides 43 229 PMID: 19375162

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关键词: Cetrorelix Acetate, Cetrorelix Acetate supplier, Potent, GnRH, antagonists, Peptide, Receptors, Gonadotropin-releasing, Hormone, gonadotrophin, Gonadotrophin-Releasing, 3536, Tocris Bioscience

篇 Cetrorelix Acetate 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Cetrorelix Acetate 的引用文献。