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Submit ReviewCGP 35348
说明： Selective GABAB antagonist; brain penetrant
化学名： (3-Aminopropyl)(diethoxymethyl)phosphinic acid
生物活性 for CGP 35348
CGP 35348 is a selective, brain penetrant GABAB receptor antagonist (IC50 = 34 μM as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors.
许可信息
Sold with the permission of Novartis Pharma AG
技术数据 for CGP 35348
| 分子量 | 225.22 |
| 公式 | C8H20NO4P |
| 储存 | Store at RT |
| CAS Number | 123690-79-9 |
| PubChem ID | 107699 |
| InChI Key | QIIVUOWTHWIXFO-UHFFFAOYSA-N |
| Smiles | NCCCP(C(OCC)OCC)(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CGP 35348
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 100 |
制备储备液 for CGP 35348
以下数据基于产品分子量 225.22。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.44 mL | 22.2 mL | 44.4 mL |
| 5 mM | 0.89 mL | 4.44 mL | 8.88 mL |
| 10 mM | 0.44 mL | 2.22 mL | 4.44 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.89 mL |
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产品说明书 for CGP 35348
参考文献 for CGP 35348
参考文献是支持产品生物活性的出版物。
Hao et al (1994) Intrathecal γ-aminobutyric acidB (GABAB) receptor antagonist CGP 35348 induces hypersensitisation to mechanical stimuli in the rat. Neurosci.Lett. 182 299 PMID: 7715832
Olpe et al (1990) CGP 35348: a centrally active blocker of GABAB receptors. Eur.J.Pharmacol. 187 27 PMID: 2176979
Staubli et al (1999) GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS. J.Neurosci. 19 4609 PMID: 10341258
Sutor and Luhmann (1998) Involvement of GABAB receptors in convulsant-induced epileptiform activity in rat neocortex in vitro. Eur.J.Neurosci. 10 3417 PMID: 9824455
If you know of a relevant reference for CGP 35348, please let us know.
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关键词: CGP 35348, CGP 35348 supplier, Brain, penetrant, selective, GABAB, antagonists, Receptors, CGP35348, 1245, Tocris Bioscience
11 篇 CGP 35348 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CGP 35348 的部分引用包括：
Lecrux et al (2011) Pyramidal neurons are "neurogenic hubs" in the neurovascular coupling response to whisker stimulation. J Neurosci 31 9836 PMID: 21734275
Zhao et al (2018) Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region. iScience 6 138 PMID: 30240608
Xia et al (2014) Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons. PLoS One 9 e100968 PMID: 24971996
Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Nat Commun 131 1050 PMID: 11082110
Gaier et al (2010) Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses. J Neurosci 30 13656 PMID: 20943906
Aubdool et al (2014) TRPA1 is essential for the vascular response to environmental cold exposure. Neuron 5 5732 PMID: 25501034
Milenković et al (2007) Development of chloride-mediated inhibition in neurons of the anteroventral cochlear nucleus of gerbil (Meriones unguiculatus). J Neurophysiol 98 1634 PMID: 17596413
Huang et al (2015) The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Br J Pharmacol 10 413 PMID: 25654758
Gantz et al (2011) Loss of Mecp2 in substantia nigra DA neurons compromises the nigrostriatal pathway. J Neurosci 31 12629 PMID: 21880923
Vashchinkina et al (2014) Neurosteroid Agonist at GABAA receptor induces persistent neuroplasticity in VTA DA neurons. Neuropsychopharmacology 39 727 PMID: 24077066
Gantz et al (2013) Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor. Cell Metab 78 807 PMID: 23764286
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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