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Submit ReviewCGP 46381
说明： Selective GABAB antagonist; brain penetrant
化学名： (3-Aminopropyl)(cyclohexylmethyl)phosphinic acid
生物活性 for CGP 46381
CGP 46381 is a brain penetrant, selective GABAB receptor antagonist (IC50 = 4.9 μM).
许可信息
Sold with the permission of Novartis Pharma AG
技术数据 for CGP 46381
| 分子量 | 219.26 |
| 公式 | C10H22NO2P |
| 储存 | Store at RT |
| CAS Number | 123691-14-5 |
| PubChem ID | 130022 |
| InChI Key | XOESDNIUAWGCLU-UHFFFAOYSA-N |
| Smiles | NCCCP(CC1CCCCC1)(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CGP 46381
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 21.93 | 100 |
制备储备液 for CGP 46381
以下数据基于产品分子量 219.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.56 mL | 22.8 mL | 45.61 mL |
| 5 mM | 0.91 mL | 4.56 mL | 9.12 mL |
| 10 mM | 0.46 mL | 2.28 mL | 4.56 mL |
| 50 mM | 0.09 mL | 0.46 mL | 0.91 mL |
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产品说明书 for CGP 46381
参考文献 for CGP 46381
参考文献是支持产品生物活性的出版物。
Curtis and Lacey (1998) Prolonged GABAB receptor-mediated synaptic inhibition in the cat spinal cord: an in vivo study. Exp.Brain Res. 121 319 PMID: 9746138
Staubli et al (1999) GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS. J.Neurosci. 19 4609 PMID: 10341258
Lingenhoehl and Olpe (1993) Blockade of the late inhibitory postsynaptic potential in vivo by the GABAB antagonist CGP 46381. Pharmacol.Comm. 3 49
Froestl et al (1996) Potent, orally active GABAB receptor antagonists. Pharmacol.Rev.Comm. 8 127
If you know of a relevant reference for CGP 46381, please let us know.
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关键词: CGP 46381, CGP 46381 supplier, Brain, penetrant, selective, GABAB, antagonist, Receptors, CGP46381, 1247, Tocris Bioscience
5 篇 CGP 46381 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CGP 46381 的部分引用包括：
Lee and Sherman (2012) Intrinsic modulators of auditory thalamocortical transmission. Hear Res 287 43 PMID: 22726616
Cheng et al (2015) GABAB receptor antagonist CGP46381 inhibits form-deprivation myopia development in guinea pigs. Front Cell Neurosci 2015 207312 PMID: 25649745
Pacey et al (2011) Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome. Biomed Res Int 338 897 PMID: 21636656
Oberlander (2016) 17β-OE Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females. J Neurosci 36 2677 PMID: 26937008
Costa et al (2008) Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition. J Neurosci 28 8040 PMID: 18685029
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