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Submit ReviewCGP 46381
说明： Selective GABAB antagonist; brain penetrant
化学名： (3-Aminopropyl)(cyclohexylmethyl)phosphinic acid
生物活性 for CGP 46381
CGP 46381 is a brain penetrant, selective GABAB receptor antagonist (IC50 = 4.9 μM).
许可信息
Sold with the permission of Novartis Pharma AG
技术数据 for CGP 46381
| 分子量 | 219.26 |
| 公式 | C10H22NO2P |
| 储存 | Store at RT |
| CAS Number | 123691-14-5 |
| PubChem ID | 130022 |
| InChI Key | XOESDNIUAWGCLU-UHFFFAOYSA-N |
| Smiles | NCCCP(CC1CCCCC1)(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CGP 46381
参考文献 for CGP 46381
参考文献是支持产品生物活性的出版物。
Curtis and Lacey (1998) Prolonged GABAB receptor-mediated synaptic inhibition in the cat spinal cord: an in vivo study. Exp.Brain Res. 121 319 PMID: 9746138
Staubli et al (1999) GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS. J.Neurosci. 19 4609 PMID: 10341258
Lingenhoehl and Olpe (1993) Blockade of the late inhibitory postsynaptic potential in vivo by the GABAB antagonist CGP 46381. Pharmacol.Comm. 3 49
Froestl et al (1996) Potent, orally active GABAB receptor antagonists. Pharmacol.Rev.Comm. 8 127
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关键词: CGP 46381, CGP 46381 supplier, Brain, penetrant, selective, GABAB, antagonist, Receptors, CGP46381, 1247, Tocris Bioscience
5 篇 CGP 46381 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CGP 46381 的部分引用包括：
Lee and Sherman (2012) Intrinsic modulators of auditory thalamocortical transmission. Hear Res 287 43 PMID: 22726616
Pacey et al (2011) Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome. Biomed Res Int 338 897 PMID: 21636656
Oberlander (2016) 17β-OE Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females. J Neurosci 36 2677 PMID: 26937008
Costa et al (2008) Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition. J Neurosci 28 8040 PMID: 18685029
Cheng et al (2015) GABAB receptor antagonist CGP46381 inhibits form-deprivation myopia development in guinea pigs. Front Cell Neurosci 2015 207312 PMID: 25649745
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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