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Submit ReviewCGP 52411
说明： EGFR inhibitor. Also inhibits Aβ42 fibril formation
别名： DAPH
化学名： 5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione
纯度： ≥99% (HPLC)
生物活性 for CGP 52411
CGP 52411 is a selective inhibitor of the epidermal growth factor receptor (EGFR) (IC50 = 0.3 μM in vitro). Also inhibits and reverses the formation of Aβ42 fibers associated with Alzheimer's disease. Eliminates calcium influx potential when coincubated with amyloid β-peptide (1-42) (Cat.No. 1428); reduces neurotoxicity by blocking Ca2+ influx into neuronal cells.
技术数据 for CGP 52411
| 分子量 | 329.35 |
| 公式 | C20H15N3O2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 145915-58-8 |
| PubChem ID | 1697 |
| InChI Key | AAALVYBICLMAMA-UHFFFAOYSA-N |
| Smiles | O=C2NC(C1=CC(NC4=CC=CC=C4)=C(NC3=CC=CC=C3)C=C12)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CGP 52411
参考文献 for CGP 52411
参考文献是支持产品生物活性的出版物。
Buchdunger et al (1994) 4,5-dianilinophthalimide: a protein tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity. Proc.Natl.Acad.Sci. 91 2334 PMID: 8134396
Blanchard et al (2004) Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule. Proc.Natl.Acad.Sci. 101 14326 PMID: 15388848
Wang et al (2008) Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc.Natl.Acad.Sci. 105 7159 PMID: 18480256
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关键词: CGP 52411, CGP 52411 supplier, abeta42, ab42, aβ42, fibers, fibres, fibrils, epidermal, growth, factors, receptors, EGFR, Alzheimers, disease, CGP52411, amyloidbeta, amyloidb, amyloidβ, DAPH, Amyloid, Beta, Peptides, 3360, Tocris Bioscience
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