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Chetomin

Cat. No. 4705 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4705 has been discontinued.

View all Hypoxia Inducible Factors (HIF) products.
说明： Blocks interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300
化学名： (3S,5aR,10bS,11aS)-2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-(3-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl)methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for Chetomin

Chetomin is a targets the CH1 domain of CBP/p300; inhibits interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300. Attenuates hypoxia-induced gene expression in vitro and in vivo; radiosensitizes human HT 1080 fibrosarcoma cells in vitro.

技术数据 for Chetomin

分子量 710.87
公式 C31H30N6O6S4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1403-36-7
PubChem ID 90488965
InChI Key ZRZWBWPDBOVIGQ-KIDIPURZSA-N
Smiles CN(C([C@@](CO)7N(C)C3=O)=O)[C@]3(SS7)CC2=CN([C@@]5(C[C@@](SS9)6C8=O)C4=CC=CC=C4N[C@@]([H])5N6C([C@@](CO)9N8C)=O)C1=CC=CC=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Chetomin

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化学品安全技术说明书

参考文献 for Chetomin

参考文献是支持产品生物活性的出版物。

Lee and Mapp (2010) Transcriptional switches: chemical approaches to gene regulation. J.Biol.Chem. 285 11033 PMID: 20147748

Kung et al (2004) Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 6 33 PMID: 15261140

Staab et al (2007) Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells. BMC Cancer 13 213 PMID: 17999771

按标靶查看相关产品

关键词: Chetomin, Chetomin supplier, NSC289491, p300/CBP, disrupts, interaction, HIF1a, HIF2a, STAT2, hypoxia, inducible, factors, hypoxic, gene, expression, Hypoxia, Inducible, Factors, 4705, Tocris Bioscience

1 篇 Chetomin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Chetomin 的部分引用包括：

Mousavizadeh et al (2016) Angiopoietin-like 4 promotes angiogenesis in the tendon and is increased in cyclically loaded tendon fibroblasts. J Physiol 594 2971 PMID: 26670924

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.