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Submit ReviewChromanol 293B is a blocker of the slow delayed rectifier K+ current (IKs) (IC50 = 1-10 μM). Also blocks the CFTR chloride current (ICFTR) (IC50 = 19 μM).
Enantiomer also available.
Chromanol 293B is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
分子量 | 324.39 |
公式 | C15H20N2O4S |
储存 | Store at RT |
纯度 | ≥98% (HPLC) |
CAS Number | 163163-23-3 |
PubChem ID | 121846 |
InChI Key | HVSJHHXUORMCGK-UONOGXRCSA-N |
Smiles | O[C@H]1[C@H](N(C)S(=O)(CC)=O)C2=C(C=CC(C#N)=C2)OC(C)1C.O[C@@H]3[C@@H](N(C)S(=O)(CC)=O)C4=C(C=CC(C#N)=C4)OC(C)3C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
ethanol | 6.49 | 20 | |
DMSO | 32.44 | 100 |
以下数据基于产品分子量 324.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 3.08 mL | 15.41 mL | 30.83 mL |
5 mM | 0.62 mL | 3.08 mL | 6.17 mL |
10 mM | 0.31 mL | 1.54 mL | 3.08 mL |
50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
参考文献是支持产品生物活性的出版物。
Bachmann et al (2001) Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKS), inhibits the CFTR Cl- current. Naunyn Schmiedebergs Arch.Pharmacol. 363 590 PMID: 11414653
Fujisawa et al (2000) Time-dependent block of the slowly activating delayed rectifier K+ current by chromanol 293B in guinea-pig ventricular cells. Br.J.Pharmacol. 129 1007 PMID: 10696102
Sun et al (2001) Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes. J.Cardiovasc.Electrophysiol. 12 472 PMID: 11332571
If you know of a relevant reference for Chromanol 293B, please let us know.
关键词: Chromanol 293B, Chromanol 293B supplier, IKs, blockers, blocks, ICFTR, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, Cl-, chloride, Chromanol293B, Voltage-Gated, CFTR, 1412, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 Chromanol 293B 的部分引用包括:
Yu et al (2014) Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents. J Cell Mol Med 9 e96691 PMID: 24798465
Neal et al (2011) Renal defects in KCNE1 knockout mice are mimicked by chromanol 293B in vivo: identification of a KCNE1-regulated K+ conductance in the proximal tubule. J Physiol 589 3595 PMID: 21576273
Inagaki et al (2019) Involvement of butyrate in electrogenic K+ secretion in rat rectal colon. Pflugers Arch 471 313 PMID: 30250967
McCallum et al (2011) The contribution of Kv7 channels to pregnant mouse and human myometrial contractility. Mol Pain 15 577 PMID: 20132415
Gage and Kobertz (2004) KCNE3 truncation mutants reveal a bipartite modulation of KCNQ1 K+ channels. J Gen Physiol 124 759 PMID: 15572349
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Chromanol 293B was used to assess how it regulates the gating kinetics of Kv2.1. The blocking action exhibited by the product was measured on epithelial Kv2.1 channels.