Chromanol 293B

Pricing Availability   Qty
说明: IKs blocker. Also blocks ICFTR
化学名: trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide
纯度: ≥98% (HPLC)
说明书
引用文献 (5)
评论 (1)

生物活性 for Chromanol 293B

Chromanol 293B is a blocker of the slow delayed rectifier K+ current (IKs) (IC50 = 1-10 μM). Also blocks the CFTR chloride current (ICFTR) (IC50 = 19 μM).

Enantiomer also available.

化合物库 for Chromanol 293B

Chromanol 293B is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Chromanol 293B

分子量 324.39
公式 C15H20N2O4S
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 163163-23-3
PubChem ID 121846
InChI Key HVSJHHXUORMCGK-UONOGXRCSA-N
Smiles O[C@H]1[C@H](N(C)S(=O)(CC)=O)C2=C(C=CC(C#N)=C2)OC(C)1C.O[C@@H]3[C@@H](N(C)S(=O)(CC)=O)C4=C(C=CC(C#N)=C4)OC(C)3C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Chromanol 293B

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 6.49 20
DMSO 32.44 100

制备储备液 for Chromanol 293B

以下数据基于产品分子量 324.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.83 mL
5 mM 0.62 mL 3.08 mL 6.17 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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参考文献 for Chromanol 293B

参考文献是支持产品生物活性的出版物。

Bachmann et al (2001) Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKS), inhibits the CFTR Cl- current. Naunyn Schmiedebergs Arch.Pharmacol. 363 590 PMID: 11414653

Fujisawa et al (2000) Time-dependent block of the slowly activating delayed rectifier K+ current by chromanol 293B in guinea-pig ventricular cells. Br.J.Pharmacol. 129 1007 PMID: 10696102

Sun et al (2001) Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes. J.Cardiovasc.Electrophysiol. 12 472 PMID: 11332571


If you know of a relevant reference for Chromanol 293B, please let us know.

关键词: Chromanol 293B, Chromanol 293B supplier, IKs, blockers, blocks, ICFTR, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, Cl-, chloride, Chromanol293B, Voltage-Gated, CFTR, 1412, Tocris Bioscience

5 篇 Chromanol 293B 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Chromanol 293B 的部分引用包括:

Yu et al (2014) Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents. J Cell Mol Med 9 e96691 PMID: 24798465

Neal et al (2011) Renal defects in KCNE1 knockout mice are mimicked by chromanol 293B in vivo: identification of a KCNE1-regulated K+ conductance in the proximal tubule. J Physiol 589 3595 PMID: 21576273

Inagaki et al (2019) Involvement of butyrate in electrogenic K+ secretion in rat rectal colon. Pflugers Arch 471 313 PMID: 30250967

McCallum et al (2011) The contribution of Kv7 channels to pregnant mouse and human myometrial contractility. Mol Pain 15 577 PMID: 20132415

Gage and Kobertz (2004) KCNE3 truncation mutants reveal a bipartite modulation of KCNQ1 K+ channels. J Gen Physiol 124 759 PMID: 15572349


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Chromanol 293B 的评论

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Chromanol 293B was used to assess how it regulates the gating kinetics of Kv2.1.
By Anonymous on 11/29/2018
分析类型: In Vitro
种属: Human

Chromanol 293B was used to assess how it regulates the gating kinetics of Kv2.1. The blocking action exhibited by the product was measured on epithelial Kv2.1 channels.

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