CI 976

Cat. No. 2227 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective ACAT inhibitor

化学名： 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide

纯度： ≥98% (HPLC)

说明书

引用文献 (2)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CI 976

CI 976 is a selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC₅₀ = 0.073 μM). Lowers non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol concentrations in rats with pre-established dyslipidemia. Orally active. Also inhibits Golgi-associated LPL acyltransferase (LPAT) activity (IC₅₀ = 15 μM).

化合物库 for CI 976

CI 976 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CI 976

分子量	393.57
公式	C₂₃H₃₉NO₄
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	114289-47-3
PubChem ID	122327
InChI Key	WAFNZAURAWBNDZ-UHFFFAOYSA-N
Smiles	CCCCCCCCCCC(C)(C)C(=O)NC1=C(OC)C=C(OC)C=C1OC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CI 976

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	ethanol	19.68	50
	DMSO	39.36	100

制备储备液 for CI 976

以下数据基于产品分子量 393.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.54 mL	12.7 mL	25.41 mL
5 mM	0.51 mL	2.54 mL	5.08 mL
10 mM	0.25 mL	1.27 mL	2.54 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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产品说明书 for CI 976

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CI 976

参考文献是支持产品生物活性的出版物。

Krause et al (1993) In vivo evidence that the lipid-regulating activity of ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT. J.Lipid Res. 34 279 PMID: 8429262

Sliskovic and White (1991) Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents. TiPS. 12 194

Drecktrah et al (2003) Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking. Mol.Biol.Cell 14 3549

If you know of a relevant reference for CI 976, please let us know.

按标靶查看相关产品

关键词: CI 976, CI 976 supplier, Acyl-CoAcholesterol, acyltransferase, ACAT, inhibitors, inhibits, Transferases, CI976, Acyl-CoA:Cholesterol, Acyltransferase, 2227, Tocris Bioscience

2 篇 CI 976 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CI 976 的部分引用包括：

Pagliuso et al (2016) Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ Nature Communications 7 12148 PMID: 27401954

Schmidt and Brown (2009) Lysophosphatidic acid acyltransferase 3 regulates Golgi complex structure and function. J Cell Biol 186 211 PMID: 19635840

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