CI 988

Cat. No. 2607 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective CCK₂ antagonist

别名： PD 134308

化学名： 4-[[(1R)-2-[[(2R)-3-(1H-indol-3-yl)-2-methyl-1-oxo-2-[[(tricyclo[3.3.1.13,7]dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]-4-oxobutanoic acid

纯度： ≥99% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CI 988

CI 988 is a potent and selective CCK₂ (CCK-B) receptor antagonist that displays ~ 1600-fold selectivity over CCK₁ receptors (IC₅₀ values are 1.7 and 2717 nM for CCK₂ and CCK₁ respectively). Has negligible affinity at a range of other binding sites (IC₅₀ > 10 μM). Exhibits anxiolytic activity following oral administration.

化合物库 for CI 988

CI 988 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CI 988

分子量	614.73
公式	C₃₅H₄₂N₄O₆
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	130332-27-3
PubChem ID	108187
InChI Key	FVQSSYMRZKLFDR-ZABPBAJSSA-N
Smiles	C[C@](NC(OC5C3CC(CC5C6)CC6C3)=O)(C(NC[C@@H]([C@]4=CC=CC=C4)NC(CCC(O)=O)=O)=O)CC2=CNC1=CC=CC=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CI 988

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	61.47	100

制备储备液 for CI 988

以下数据基于产品分子量 614.73。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.63 mL	8.13 mL	16.27 mL
5 mM	0.33 mL	1.63 mL	3.25 mL
10 mM	0.16 mL	0.81 mL	1.63 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

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产品说明书 for CI 988

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CI 988

参考文献是支持产品生物活性的出版物。

Moody et al (2001) CI-988 inhibits growth of small cell lung cancer cells. J.Pharmacol.Exp.Ther. 299 1154 PMID: 11714907

Andre et al (2005) Involvement of cholecystokininergic systems in anxiety-induced hyperalgesia in male rats: behavioral and biochemical studies. J.Neurosci. 25 7896 PMID: 16135746

Hughes et al (1990) Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity. Proc.Natl.Acad.Sci.USA 87 6728

If you know of a relevant reference for CI 988, please let us know.

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关键词: CI 988, CI 988 supplier, Potent, selective, CCK2, antagonists, Cholecystokinin2, Receptors, CI988, PD134308, PD, 134308, Receptor, 2607, Tocris Bioscience

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