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Submit ReviewCI 994
说明： Class I histone deacetylase inhibitor; orally active
别名： N-acetyldinaline
化学名： 4-(Acetylamino)-N-(2-aminophenyl)benzamide
纯度： ≥99% (HPLC)
生物活性 for CI 994
CI 994 is an orally active class I histone deacetylase (HDAC) inhibitor (Ki values are 0.41, 0.75, >100 and >100 μM for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo. Increases neuroplasticity during memory extinction. Also increases efficiency of hepatic differentiation of hPSCs
化合物库 for CI 994
CI 994 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for CI 994
| 分子量 | 269.3 |
| 公式 | C15H15N3O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 112522-64-2 |
| PubChem ID | 2746 |
| InChI Key | VAZAPHZUAVEOMC-UHFFFAOYSA-N |
| Smiles | O=C(NC2=C(N)C=CC=C2)C1=CC=C(NC(C)=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CI 994
参考文献 for CI 994
参考文献是支持产品生物活性的出版物。
Beckers et al (2007) Distinct pharamacologcial properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. Int.J.Cancer 121 1138 PMID: 17455259
Gräff et al (2014) Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell 156 261 PMID: 24439381
Kraker et al (2003) Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benamide] in HCT-8 colon carcinoma. Mol.Cancer Ther. 2 401 PMID: 12700284
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关键词: CI 994, CI 994 supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, Class, I, CI994, epigenetics, HDAC1, HDAC2, HDAC3, HDAC8, hepatocyte, differentiation, N-acetyldinaline, HDACs, Hepatocyte, Stem, Cells, 2952, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Epigenetics in Cancer Poster
This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.