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说明： Glucocorticoid antiasthmatic prodrug
化学名： (11β,16α)-16,17-[[(R)-Cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione
纯度： ≥98% (HPLC)
生物活性 for Ciclesonide
Ciclesonide is a glucocorticoid antiasthmatic prodrug; de-esterified in the lung to active metabolite. Anti-inflammatory. Also blocks replication of SARS-CoV-2 in Vero cells in vitro by targeting viral NSP-15 (EC90 = 6.3μM)..
化合物库 for Ciclesonide
Ciclesonide is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Ciclesonide
| 分子量 | 540.7 |
| 公式 | C32H44O7 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 126544-47-6 |
| PubChem ID | 6918155 |
| InChI Key | LUKZNWIVRBCLON-GXOBDPJESA-N |
| Smiles | [H][C@@]1(C2CCCCC2)O[C@]3([H])C[C@@]4([H])[C@]5([H])CCC6=CC(C=C[C@]6(C)[C@@]5([H])[C@@H](O)C[C@]4(C)[C@]3(C(COC(C(C)C)=O)=O)O1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Ciclesonide
参考文献 for Ciclesonide
参考文献是支持产品生物活性的出版物。
Stoeck et al (2004) In vitro and in vivo anti-inflammatory activity of the new glucocorticoid cicles. J.Pharmacol.Exp.Ther. 309 249 PMID: 14718604
Matsuyama et al (2020) The inhaled steroid ciclesonide blocks SARS-CoV-2 RNA replication by targeting the viral replication-transcription complex in cultured cells. J.Virol. 95 e01648 PMID: 33055254
关键词: Ciclesonide, Ciclesonide supplier, Glucocorticoid, antiasthmatic, prodrug, anti-inflammatory, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, Receptor, Coronavirus, 6357, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.