主页 / 药理学 / Nuclear Receptors / Glucocorticoid Receptors / Ciclesonide

Ciclesonide

Cat. No. 6357 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Glucocorticoid antiasthmatic prodrug
化学名： (11β,16α)-16,17-[[(R)-Cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ciclesonide

Ciclesonide is a glucocorticoid antiasthmatic prodrug; de-esterified in the lung to active metabolite. Anti-inflammatory. Also blocks replication of SARS-CoV-2 in Vero cells in vitro by targeting viral NSP-15 (EC90 = 6.3μM)..

化合物库 for Ciclesonide

Ciclesonide is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Ciclesonide

分子量 540.7
公式 C32H44O7
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 126544-47-6
PubChem ID 6918155
InChI Key LUKZNWIVRBCLON-GXOBDPJESA-N
Smiles [H][C@@]1(C2CCCCC2)O[C@]3([H])C[C@@]4([H])[C@]5([H])CCC6=CC(C=C[C@]6(C)[C@@]5([H])[C@@H](O)C[C@]4(C)[C@]3(C(COC(C(C)C)=O)=O)O1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ciclesonide

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 54.07 100
ethanol 54.07 100

制备储备液 for Ciclesonide

以下数据基于产品分子量 540.7。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.85 mL 9.25 mL 18.49 mL
5 mM 0.37 mL 1.85 mL 3.7 mL
10 mM 0.18 mL 0.92 mL 1.85 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for Ciclesonide

参考文献是支持产品生物活性的出版物。

Stoeck et al (2004) In vitro and in vivo anti-inflammatory activity of the new glucocorticoid cicles. J.Pharmacol.Exp.Ther. 309 249 PMID: 14718604

Matsuyama et al (2020) The inhaled steroid ciclesonide blocks SARS-CoV-2 RNA replication by targeting the viral replication-transcription complex in cultured cells. J.Virol. 95 e01648 PMID: 33055254

If you know of a relevant reference for Ciclesonide, please let us know.

按标靶查看相关产品

关键词: Ciclesonide, Ciclesonide supplier, Glucocorticoid, antiasthmatic, prodrug, anti-inflammatory, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, Receptor, Coronavirus, 6357, Tocris Bioscience

篇 Ciclesonide 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Ciclesonide 的引用文献。 您是否知道使用了 Tocris Ciclesonide 的优秀论文？ 请告知我们.

Ciclesonide 的评论

目前没有该产品的评论。 Be the first to review Ciclesonide and earn rewards!

Have you used Ciclesonide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.