CID 2745687

Pricing Availability   Qty
说明: GPR35 antagonist
化学名: 1-(2,4-Difluorophenyl)-5-[[2-[[(1,1-dimethylehyl)amino]thioxomethyl]hydrazinylidene]methyl]-1H-pyrazole-4-carboxylic acid methyl ester
纯度: ≥98% (HPLC)
说明书
引用文献 (1)
评论

生物活性 for CID 2745687

CID 2745687 is a competitive, reversible antagonist of the orphan receptor GPR35 (Ki = 12.8 nM). Blocks the GPR35-mediated increase in ERK1/2 phosphorylation and β-arrestin recruitment induced by pamoic acid.

化合物库 for CID 2745687

CID 2745687 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CID 2745687

分子量 395.43
公式 C17H19F2N5O2S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 264233-05-8
PubChem ID 9581011
InChI Key CYNLZIBKERMMOA-AWQFTUOYSA-N
Smiles FC1=CC(F)=CC=C1N2C(/C=N/NC(NC(C)(C)C)=S)=C(C(OC)=O)C=N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CID 2745687

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.54 100
ethanol 3.95 10

制备储备液 for CID 2745687

以下数据基于产品分子量 395.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.64 mL 25.29 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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产品说明书 for CID 2745687

分析证书/产品说明书
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参考文献 for CID 2745687

参考文献是支持产品生物活性的出版物。

Zhao et al (2010) Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol.Pharmacol. 78 560 PMID: 20826425

Jenkins et al (2012) Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J.Pharmacol.Exp.Ther. 343 683 PMID: 22967846


If you know of a relevant reference for CID 2745687, please let us know.

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关键词: CID 2745687, CID 2745687 supplier, CID2745687, orphan, receptors, antagonists, GPR35, antagonist, 4293, Tocris Bioscience

1 篇 CID 2745687 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CID 2745687 的部分引用包括:

Sun et al (2014) Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel. Sci Rep 4 4934 PMID: 24816792


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