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CID 2858522

Cat. No. 4246 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4246 has been discontinued.

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说明： Selectively inhibits PKC-induced NF-κB activation
化学名： 1-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dimethyl-1H-benzimidazol-1-yl]ethanone
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for CID 2858522

CID 2858522 is a selectively inhibits protein kinase C (PKC)-induced activation of the NF-κB pathway (IC50 < 0.1 μM for PMA-stimulated IL-8 production). Inhibits antigen receptor-stimulated NF-κB activation in chronic lymphocytic leukemia (CLL) B cells. Does not inhibit other NF-κB pathways, including that activated by tumor necrosis factor (TNF).

技术数据 for CID 2858522

分子量 465.63
公式 C28H39N3O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 758679-97-9
PubChem ID 2858523
InChI Key CYCGGKILBWERDJ-UHFFFAOYSA-N
Smiles OCCCNC2=NC1=CC(C)=C(C)C=C1N2CC(C3=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for CID 2858522

参考文献是支持产品生物活性的出版物。

Peddibhotla et al (2010) Inhibition of protein kinase C-driven NF-κB activation: synthesis, SAR, and pharmacological profiling of pathway specific benzimidazole probe molecules. J.Med.Chem. 53 4793 PMID: 20481485

Shi et al (2010) Chemical biology strategy reveals pathway-selective inhibitor of NF-κB activation induced by protein kinase C and antigen receptors. ACS Chem.Bio. 5 287

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关键词: CID 2858522, CID 2858522 supplier, CID2858522, NF-kB, NF-kappaB, NF-κB, inhibitors, inhibits, PKC, protein, kinase, C-induced, activation, NF-kB/IkB, 4246, Tocris Bioscience

1 篇 CID 2858522 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CID 2858522 的部分引用包括：

Stec et al (2016) Cell line with endogenous EGFRvIII expression is a suitable model for research and drug development purposes. Oncotarget 7 31907 PMID: 27004406

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Pathways for CID 2858522

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.