Cinacalcet hydrochloride

Cat. No. 6170 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Allosteric Calcium-sensing receptor (CaSR) agonist; also CYP2D2 inhibitor and Ca²⁺ channel blocker; orally bioavailable

别名： AMG 073

化学名： N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride

纯度： ≥98% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Cinacalcet hydrochloride

Cinacalcet hydrochloride is a calcium-sensing receptor (CaSR) allosteric agonist. Activates CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays. Reduces serum parathyroid hormone levels in rats. Also potent CYP2D2 inhibitor (IC₅₀ = 87 nM) and L-type calcium channel blocker. Orally bioavailable.

化合物库 for Cinacalcet hydrochloride

Cinacalcet hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Cinacalcet hydrochloride

分子量	393.87
公式	C₂₂H₂₂F₃N.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	364782-34-3
PubChem ID	156418
InChI Key	QANQWUQOEJZMLL-PKLMIRHRSA-N
Smiles	C[C@H](C1=CC=CC2=C1C=CC=C2)NCCCC3=CC(C(F)(F)F)=CC=C3.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cinacalcet hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	39.39	100

制备储备液 for Cinacalcet hydrochloride

以下数据基于产品分子量 393.87。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.54 mL	12.69 mL	25.39 mL
5 mM	0.51 mL	2.54 mL	5.08 mL
10 mM	0.25 mL	1.27 mL	2.54 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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产品说明书 for Cinacalcet hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Cinacalcet hydrochloride

参考文献是支持产品生物活性的出版物。

Goodman et al (2002) The calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism. J.Am.Soc.Nephrol. 13 1017 PMID: 11912261

Ma et al (2011) Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor. J.Pharmacol.Exp.Ther. 337 275 PMID: 21239511

If you know of a relevant reference for Cinacalcet hydrochloride, please let us know.

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关键词: Cinacalcet hydrochloride, Cinacalcet hydrochloride supplier, AMG073, calcium-sensing, receptor, CaSR, allosteric, agonists, agonism, calcimimetic, CYP2D2, inhibitors, inhibits, L-type, calcium, channel, blockers, Sensipar, AMG, 073, Calcium-Sensing, Receptor, Cytochrome, P450, Cav1.x, Channels, 6170, Tocris Bioscience

2 篇 Cinacalcet hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Cinacalcet hydrochloride 的部分引用包括：

Ian P et al (2023) Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cell Signal 107 110676 PMID: 37028778

Stephen D et al (2021) Area Postrema Cell Types that Mediate Nausea-Associated Behaviors. Neuron 109 461-472.e5 PMID: 33278342

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