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CITFA

Cat. No. 7811 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent G protein-coupled estrogen receptor (GPER) agonist
化学名： N-[2-Cyclohexyl-4-(1-methylethyl)phenyl]-5-(tetrahydro-2H-pyran-2-yl)-2-furanmethanamine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CITFA

CITFA is a potent GPER agonist (EC50 = 38.7 nM). It significantly increases axonal and dendritic growth in rat embryonic (E18) hippocampal neurons.

许可信息

Sold under licence from Saint Louis University.

化合物库 for CITFA

CITFA is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CITFA

分子量 381.56
公式 C25H35NO2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2379989-52-1
PubChem ID 153360510
InChI Key GYTVCHRGONLGMD-UHFFFAOYSA-N
Smiles CC(C)C(C=C1C2CCCCC2)=CC=C1NCC3=CC=C(C4OCCCC4)O3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CITFA

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 19.08 50
ethanol 3.82 10

制备储备液 for CITFA

以下数据基于产品分子量 381.56。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.24 mL 26.21 mL 52.42 mL
2.5 mM 1.05 mL 5.24 mL 10.48 mL
5 mM 0.52 mL 2.62 mL 5.24 mL
25 mM 0.1 mL 0.52 mL 1.05 mL

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参考文献 for CITFA

参考文献是支持产品生物活性的出版物。

DeLeon et al (2022) Novel GPER agonist, CITFA, increases neurite growth in rat embryonic (E18) hippocampal neurons. ACS Chem.Neurosci. 13 1119 PMID: 35353510

If you know of a relevant reference for CITFA, please let us know.

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关键词: CITFA, CITFA supplier, Potent, GPER, agonists, agonism, estrogen, oestrogen, neurite, growth, Estrogen, (GPER), Receptors, 7811, Tocris Bioscience

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Pathways for CITFA

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.