Clemastine fumarate

Cat. No. 1453 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： H₁ antagonist

化学名： (2R)-2-[2-[(1R)-1-(4-Chlorophenylethoxy]ethyl]-1-methyl-2-pyrrolidine fumarate

纯度： ≥98% (HPLC)

引用文献 (2)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Clemastine fumarate

Clemastine fumarate is a h₁-receptor antagonist. Enhances differentiation of oligodendrocyte progenitor cells into myelin basic protein-positive oligodendrocytes in vitro and promotes remyelination in vivo. Also displays antimuscarinic properties. Clinically-used antihistamine.

化合物库 for Clemastine fumarate

Clemastine fumarate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Clemastine fumarate

分子量	459.97
公式	C₂₁H₂₆ClNO.C₄H₄O₄
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	14976-57-9
PubChem ID	5281069
InChI Key	PMGQWSIVQFOFOQ-YKVZVUFRSA-N
Smiles	[H]OC(=O)\C=C\C(=O)O[H].CN1CCC[C@@H]1CCO[C@](C)(C1=CC=CC=C1)C1=CC=C(Cl)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Clemastine fumarate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	9.2	20

制备储备液 for Clemastine fumarate

以下数据基于产品分子量 459.97。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	10.87 mL	54.35 mL	108.7 mL
1 mM	2.17 mL	10.87 mL	21.74 mL
2 mM	1.09 mL	5.44 mL	10.87 mL
10 mM	0.22 mL	1.09 mL	2.17 mL

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产品说明书 for Clemastine fumarate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Clemastine fumarate

参考文献是支持产品生物活性的出版物。

Dorsch et al (1982) Histamine1-histamine2 antagonism: effect of combined clemastine and cimetidine pretreatment on allergen and histamine-induced reactions of the guinea pig lung in vivo and in vitro. Agents Actions 12 113 PMID: 6177209

Hartmann et al (1981) Modulation of histamine-induced bronchoconstriction with inhaled, oral, and intravenous clemastine in normal and asthmatic subjects. Thorax 36 737 PMID: 7330790

Nair and Schwartz (1983) Effect of histamine and histamine antagonists on natural and antibody-dependent cellular cytotoxicity of human lymphocytes in vitro. Cell.Immunol. 81 45 PMID: 6225527

If you know of a relevant reference for Clemastine fumarate, please let us know.

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关键词: Clemastine fumarate, Clemastine fumarate supplier, H1, antagonist, Receptors, Histamine, antihistamine, histaminergic, promotes, oligodendrocyte, differentiation, remyelination, Other, Differentiation, Products, 1453, Tocris Bioscience

2 篇 Clemastine fumarate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Clemastine fumarate 的部分引用包括：

Nörenberg et al (2011) Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations. J Biol Chem 286 11067 PMID: 21262970

Bisikirska et al (2016) Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression. Cancer Res 76 664 PMID: 26589882

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