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Submit ReviewCLP 290 is a K+/Cl- Cotransporter 2 (KCC2) activator. Activates spinal inhibitory interneurons, restores physiological neuronal activity in the spinal cord and induces functional recovery in a mouse model of spinal cord injury. Also decreases blood vasopressin and glucose levels in mice with Streptozotocin (Cat. No. 1621) induced diabetes mellitus. Orally bioavailable prodrug of CLP 257 (Cat. No.5242).
CLP 290 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
分子量 | 404.46 |
公式 | C19H21FN4O3S |
储存 | Store at -20°C |
纯度 | ≥98% (HPLC) |
CAS Number | 1181083-81-7 |
PubChem ID | 68637267 |
InChI Key | DIXMMXNNKLCLOM-WJDWOHSUSA-N |
Smiles | FC1=CC(OC(N2CCCC2)=O)=C(C=C1)/C=C3SC(N4CCCCN4)=NC\3=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 20.22 | 50 | |
ethanol | 2.02 | 5 |
以下数据基于产品分子量 404.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.5 mM | 4.94 mL | 24.72 mL | 49.45 mL |
2.5 mM | 0.99 mL | 4.94 mL | 9.89 mL |
5 mM | 0.49 mL | 2.47 mL | 4.94 mL |
25 mM | 0.1 mL | 0.49 mL | 0.99 mL |
参考文献是支持产品生物活性的出版物。
Gagnon et al (2013) Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat.Med. 19 1524 PMID: 24097188
Kim et al (2019) Long-term ionic plasticity of GABAergic signalling in the hypothalamus. J.Neuroendocrinol. 31 e12753 PMID: 31166034
Chen et al (2018) Reactivation of dormant relay pathways in injured spinal cord by KCC2 manipulations. Cell 174 521 PMID: 30033363
If you know of a relevant reference for CLP 290, please let us know.
关键词: CLP 290, CLP 290 supplier, CLP290, CLP257, Selective, KCC2, K+/Cl-, cotransporters, activators, activates, neuropathic, pain, orally, bioavailable, Cotransporter, 2, 6758, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.