CMPD-1

Name: CMPD-1
Brand: Tocris Bioscience
SKU: 2186
Rating: 4 (1 reviews)

Cat. No. 2186 3 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective inhibitor of p38α-mediated MK2a phosphorylation; also tubulin polymerization inhibitor

化学名： 2'-Fluoro-N-(4-hydroxyphenyl)-[1,1'-biphenyl]-4-butanamide

纯度： ≥99% (HPLC)

说明书

引用文献 (3)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CMPD-1

CMPD-1 is a non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent K_i = 330 nM). Does not inhibit p38α-mediated phosphorylation of MBP and ATF-2. Also tubulin polymerization inhibitor. Cytotoxic in glioblastoma cells at concentrations that do not affect the MK2 pathway.

化合物库 for CMPD-1

CMPD-1 is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for CMPD-1

分子量	349.4
公式	C₂₂H₂₀FNO₂
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	41179-33-3
PubChem ID	11382492
InChI Key	ODYAQBDIXCVKAE-UHFFFAOYSA-N
Smiles	OC1=CC=C(NC(=O)CCCC2=CC=C(C=C2)C2=CC=CC=C2F)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CMPD-1

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	34.94	100
	ethanol	34.94	100

制备储备液 for CMPD-1

以下数据基于产品分子量 349.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.86 mL	14.31 mL	28.62 mL
5 mM	0.57 mL	2.86 mL	5.72 mL
10 mM	0.29 mL	1.43 mL	2.86 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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产品说明书 for CMPD-1

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CMPD-1

参考文献是支持产品生物活性的出版物。

Davidson et al (2004) Discovery and characterisation of a substrate selective p38α inhibitor. Biochemistry 43 11658 PMID: 15362850

Gurgis et al (2015) Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2. Cell Death Discovery 1 15028

If you know of a relevant reference for CMPD-1, please let us know.

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查看全部 p38 MAPK Inhibitors

关键词: CMPD-1, CMPD-1 supplier, Non-ATP-competitive, p38α, p38alpha, inhibitors, inhibits, Mitogen-Activated, Protein, Kinase, p38, MAPK, Kinases, Signaling, Signalling, Microtubules, MK2, 2186, Tocris Bioscience

3 篇 CMPD-1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CMPD-1 的部分引用包括：

Ryals et al (2018) The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity. Front Cell Neurosci 12 445 PMID: 30532693

Breindel et al (2013) EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. Cancer Res 73 5053 PMID: 23794705

Fricke et al (2013) p38 and OGT sequestration into viral inclusion bodies in cells infected with human respiratory syncytial virus suppresses MK2 activities and stress granule assembly. J Virol 87 1333 PMID: 23152511

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CMPD-1 的评论

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Filter by:

42 perturbagens used the zebrafish DASPEI screen.

By Anonymous on 12/17/2019

分析类型： In Vivo

种属： Other

细胞系/组织： larvae

Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound

PMID: 30532693

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for CMPD-1

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.