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Submit ReviewCOG 133
说明： ApoE peptide fragment
别名： apoE(133-149)
纯度： ≥95% (HPLC)
生物活性 for COG 133
COG 133 is an apolipoprotein (ApoE) peptide fragment that functions via the low-density lipoprotein receptor-related protein (LRP). Substantially reduces the symptoms of experimental autoimmune encephalomyelitis, a model of human multiple sclerosis, and suppresses inflammation, demyelination and infiltration of cells into the spinal cord. Also acts as a non-competitive antagonist at α7 nicotinic acetylcholine receptors (IC50 = 445 nM).
技术数据 for COG 133
| 分子量 | 2169.73 |
| 公式 | C97H181N37O19 |
| 序列 |
LRVRLASHLRKLRKRLL (Modifications: Leu-1 = N-terminal Ac, Leu-17 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 514200-66-9 |
| PubChem ID | 16201427 |
| InChI Key | QTWXJKVJIKDSLC-KIZXDXQLSA-N |
| Smiles | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for COG 133
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for COG 133
参考文献 for COG 133
参考文献是支持产品生物活性的出版物。
Gay et al (2006) Apolipoprotein E-derived peptides block α7 neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J.Pharmacol.Exp.Ther. 316 835 PMID: 16249370
Li et al (2006) Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis. J.Pharmacol.Exp.Ther. 318 956 PMID: 16740622
Sheng et al (2008) N-MthD.-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein. Neuropharmacology 55 204 PMID: 18602124
If you know of a relevant reference for COG 133, please let us know.
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关键词: COG 133, COG 133 supplier, apoE, peptide, fragment, α7, alpha7, a7, nAChR, antagonists, NMDA, Nicotinic, Receptors, Acetylcholine, Glutamate, N-Methyl-D-Aspartate, iGluR, Ionotropic, COG133, apoE(133149), LDL, lipoprotein, apolipoproteins, apoE(133-149), (a7), 3405, Tocris Bioscience
1 篇 COG 133 的引用文献
引用文献是使用了 Tocris 产品的出版物。 COG 133 的部分引用包括：
Tavazoie et al (2018) LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer. Cell 172 825 PMID: 29336888
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