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Submit ReviewColchicine is a plant-derived alkaloid that binds to tubulin and depolymerizes microtubules. Identified as a candidate for repurposing for COVID-19. Inhibits NLRP3 inflammasomes. Also decreases TNF-α receptor expression and reduces cytokine levels in macrophages. Anti-inflammatory.
分子量 | 399.44 |
公式 | C22H25NO6 |
储存 | Store at RT |
纯度 | ≥98% (HPLC) |
CAS Number | 64-86-8 |
PubChem ID | 2833 |
InChI Key | IAKHMKGGTNLKSZ-UHFFFAOYSA-N |
Smiles | COC1=C(OC)C(OC)=C2C(CCC(NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
water | 39.94 | 100 | |
DMSO | 39.94 | 100 |
以下数据基于产品分子量 399.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.5 mL | 12.52 mL | 25.04 mL |
5 mM | 0.5 mL | 2.5 mL | 5.01 mL |
10 mM | 0.25 mL | 1.25 mL | 2.5 mL |
50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
参考文献是支持产品生物活性的出版物。
Bai et al (1996) Identification of cysteine 354 of β-tubulin as part of the binding site for the A ring of colch. J.Biol.Chem. 271 12639 PMID: 8647876
Burns (1992) Analysis of the colchicine-binding site of β-tubulin. FEBS Lett. 297 205 PMID: 1544399
Hastie (1991) Interactions of colch. with tubulin. Pharmacol.Ther. 51 377 PMID: 1792241
Morselli et al (2021) Network medicine framework for identifying drug repurposing opportunities for COVID-19. Proc.Nat.Acad.Sci.U.S.A. 118 PMID: 33906951
Ribeiro et al (2020) The therapeutic potential of colch in the complications of COVID19. Could the immunometabolic properties of an old and cheap drug help? Metabol.Open 7 100045 PMID: 32808940
Martinez et al (2018) The NLRP3 inflammasome and the emerging role of colch to inhibit atherosclerosis-associated inflammation. Atherosclerosis 269 262 PMID: 29352570
If you know of a relevant reference for Colchicine, please let us know.
关键词: Colchicine, Colchicine supplier, inhibitors, inhibits, tubulin, Tau, Tubulin, Microtubules, Mitosis, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, inflammasome, NLRP3, Inflammasomes, 1364, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 Colchicine 的部分引用包括:
Melemedjian et al (2014) Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity. Mol Pain 10 45 PMID: 24993495
Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther 16 1021 PMID: 28265007
Kathawala et al (2015) The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study. Oncotarget 6 510 PMID: 25402202
Khan et al (2016) Genetic screening reveals a link between Wnt signaling and antitubulin drugs. Pharmacogenomics J 16 164 PMID: 26149735
Park et al (2016) Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol 17 914 PMID: 27270401
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Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for: