Conivaptan hydrochloride

Cat. No. 6830 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Very high affinity vasopressin V_1A and V₂ antagonist; orally bioavailable

化学名： N-[4-[(4,5-Dihydro-2-methylimidazo[4,5-d][benzazepin-6(1H)-yl)carbonyl]phenyl-[1,1'-biphenyl]-2-carboxamide hydrochloride

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Conivaptan hydrochloride

Conivaptan hydrochloride is a very high affinity vasopressin V_1A and V₂ antagonist (K_i values are 0.61 and 0.66 - 3.04 nM, respectively). Inhibits vasopressin-induced pressor responses in rats without altering blood pressure, and increases urine flow while decreasing urine osmolality. Orally bioavailable.

化合物库 for Conivaptan hydrochloride

Conivaptan hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Conivaptan hydrochloride

分子量	535.04
公式	C₃₂H₂₆N₄O₂.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	168626-94-6
PubChem ID	151171
InChI Key	IKENVDNFQMCRTR-UHFFFAOYSA-N
Smiles	CC1=NC2=C(C3=CC=CC=C3N(C(C4=CC=C(C=C4)NC(C5=C(C6=CC=CC=C6)C=CC=C5)=O)=O)CC2)N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Conivaptan hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	53.5	100
	ethanol	10.7	20 温和加热

制备储备液 for Conivaptan hydrochloride

以下数据基于产品分子量 535.04。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.87 mL	9.35 mL	18.69 mL
5 mM	0.37 mL	1.87 mL	3.74 mL
10 mM	0.19 mL	0.93 mL	1.87 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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产品说明书 for Conivaptan hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Conivaptan hydrochloride

参考文献是支持产品生物活性的出版物。

Tahara et al (1997) Pharmacological profile of YM087, a novel potent nonpeptide vasopressin V_1A and V₂ receptor antagonist, in vitro and in vivo. J.Pharmacol.Exp.Ther. 282 301 PMID: 9223568

Yatsu et al (1997) Pharmacological profile of YM087, a novel nonpeptide dual vasopressin V_1A and V₂ receptor antagonist, in dogs. Eur.J.Pharmacol. 321 225 PMID: 9063692

If you know of a relevant reference for Conivaptan hydrochloride, please let us know.

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