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Submit ReviewCorticosterone
说明： Endogenous glucocorticoid
化学名： (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione
纯度： ≥99% (HPLC)
生物活性 for Corticosterone
Corticosterone is an endogenous glucocorticoid that acts as an agonist at glucocorticoid and mineralocorticoid receptors.
化合物库 for Corticosterone
Corticosterone is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Corticosterone
| 分子量 | 346.46 |
| 公式 | C21H30O4 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 50-22-6 |
| PubChem ID | 5753 |
| InChI Key | OMFXVFTZEKFJBZ-HJTSIMOOSA-N |
| Smiles | [H][C@@]23CCC1=CC(CC[C@@](C)1[C@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3CC[C@@H]4[C@@](CO)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Corticosterone
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 34.65 | 100 |
制备储备液 for Corticosterone
以下数据基于产品分子量 346.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.89 mL | 14.43 mL | 28.86 mL |
| 5 mM | 0.58 mL | 2.89 mL | 5.77 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.89 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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产品说明书 for Corticosterone
参考文献 for Corticosterone
参考文献是支持产品生物活性的出版物。
Lu et al (2006) International union of pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacol.Rev. 58 782 PMID: 17132855
If you know of a relevant reference for Corticosterone, please let us know.
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关键词: Corticosterone, Corticosterone supplier, endogenous, glucocorticoid, receptors, mineralocorticoid, nuclear, steroid, hormone, Glucocorticoid, Receptor, Mineralocorticoid, 3685, Tocris Bioscience
4 篇 Corticosterone 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Corticosterone 的部分引用包括：
Ahmad et al (2019) Perivascular Adipocytes Store Norepinephrine by Vesicular Transport. Arterioscler Thromb Vasc Biol 39 188 PMID: 30567483
Gang et al (2021) Bag-1 mediates glucocorticoid receptor trafficking to mitochondria after corticosterone stimulation: Potential role in regulating affective resilience. J Neurochem 158 358-372 PMID: 33025573
Roshanak et al (2019) Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy. Elife 8 PMID: 31433293
Shikatani et al (2012) Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis. PLoS One 7 e46625 PMID: 23056375
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Corticosterone 的评论
平均评分: 5 (Based on 1 Review.)
Have you used Corticosterone?
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works well.
By
Anonymous on 03/29/2020
分析类型： In Vitro
种属： Rat
细胞系/组织： rat adrenal medulla chromaffin cells
1 mM
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.