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Submit ReviewCP 316819
说明： Selective glycogen phosphorylase inhibitor
化学名： 5-Chloro-N-[(1S,2R)-2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide
纯度： ≥98% (HPLC)
生物活性 for CP 316819
CP 316819 is a selective glycogen phosphorylase inhibitor [IC50 values are 0.017 and 0.034 μM against human skeletal muscle glycogen phosphorylase a (huSMGPa) and liver glycogen phosphorylase a (huLGPa) respectively]. Antihyperglycemic agent.
化合物库 for CP 316819
CP 316819 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for CP 316819
| 分子量 | 415.87 |
| 公式 | C21H22ClN3O4 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 186392-43-8 |
| PubChem ID | 10273347 |
| InChI Key | WEQLRDLTRCEUHG-PKOBYXMFSA-N |
| Smiles | O=C(N[C@@H](CC3=CC=CC=C3)[C@H](C(N(OC)C)=O)O)C2=CC1=CC(Cl)=CC=C1N2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CP 316819
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 41.59 | 100 | |
| ethanol | 41.59 | 100 |
制备储备液 for CP 316819
以下数据基于产品分子量 415.87。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.4 mL | 12.02 mL | 24.05 mL |
| 5 mM | 0.48 mL | 2.4 mL | 4.81 mL |
| 10 mM | 0.24 mL | 1.2 mL | 2.4 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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产品说明书 for CP 316819
参考文献 for CP 316819
参考文献是支持产品生物活性的出版物。
Baker et al (2005) Glycogen phosphorylase inhibition in type 2 diabetes therapy: a systematic evaluation of metabolic and functional effects in rat skeletal muscle. Diabetes 54 2453 PMID: 16046314
Freeman et al (2006) Sensitivity of glycogen phosphorylase isoforms to indole site inhibitors is markedly dependent on the activation site of the enzyme. Br.J.Pharmacol. 149 775 PMID: 17016495
Suh et al (2007) Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*,S*]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-ca J.Pharmacol.Exp.Ther. 321 45 PMID: 17251391
If you know of a relevant reference for CP 316819, please let us know.
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关键词: CP 316819, CP 316819 supplier, glycogen, phosphorylase, inhibitors, inhibits, antihyperglycemic, antihyperglycaemic, transferases, carbohydrate, metabolism, CP316819, Phosphorylases, 3542, Tocris Bioscience
2 篇 CP 316819 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CP 316819 的部分引用包括：
Jun et al (2021) Glycogen metabolism is dispensable for tumour progression in clear cell renal cell carcinoma. Nat Metab 3 327-336 PMID: 33758423
Galow et al (2014) Energy substrates that fuel fast neuronal network oscillations. J Exp Bot 8 398 PMID: 25538552
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