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Submit ReviewCP 471474
说明： Broad spectrum MMP inhibitor
化学名： 2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide
纯度： ≥97% (HPLC)
生物活性 for CP 471474
CP 471474 is a broad spectrum MMP inhibitor (IC50 values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infarction in mice.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for CP 471474
| 分子量 | 368.38 |
| 公式 | C16H17FN2O5S |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 210755-45-6 |
| PubChem ID | 9907286 |
| InChI Key | QCOQJYRPDUMCNP-UHFFFAOYSA-N |
| Smiles | FC1=CC=C(OC2=CC=C(S(NC(C)(C)C(NO)=O)(=O)=O)C=C2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CP 471474
参考文献 for CP 471474
参考文献是支持产品生物活性的出版物。
Rohde et al (1999) Matrix metalloproteinease inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice. Circulation 99 3063 PMID: 10368126
Lindsey et al (2002) Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction. Circulation 105 753 PMID: 11839633
Fang et al (2007) Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction. J.Mol.Cell.Cardiol. 43 535 PMID: 17689559
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关键词: CP 471474, CP 471474 supplier, CP471474, MMP, matrix, metalloproteinase, metalloprotease, inhibitors, inhibits, broad, spectrum, proteinases, proteases, Pfizer, Matrix, Metalloprotease, 3780, Tocris Bioscience
3 篇 CP 471474 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CP 471474 的部分引用包括：
Brafman et al (2013) Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. PLoS One 20 369 PMID: 23154389
Meierjohann et al (2010) MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation. Mol Cancer 9 201 PMID: 20667128
Zariffard et al (2015) Cleavage/Alteration of interleukin-8 by matrix metalloproteinase-9 in the female lower genital tract. PLoS One 10 e0116911 PMID: 25611319
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Angiogenesis in Cancer Poster
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