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CP 673451

Cat. No. 5993 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective PDGFR inhibitor
化学名： 1-[2-[5-(2-Methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CP 673451

CP 673451 is a potent and selective PDGFR inhibitor (IC50 values are 1 and 10 nM for PDGFR-β and -α respectively). Selective for PDGFR kinase over a range of related kinases. Inhibits PDGFR-β phosphorylation in glioblastoma xenografts and PDGF-induced angiogenesis in mice.

External Portal Information for CP 673451

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP 673451 is reviewed on the Chemical Probes website.

化合物库 for CP 673451

CP 673451 is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for CP 673451

分子量 417.5
公式 C24H27N5O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 343787-29-1
PubChem ID 10158940
InChI Key DEEOXSOLTLIWMG-UHFFFAOYSA-N
Smiles COCCOC1=CC=C2N(C3=NC4=C(C=C3)C=CC=C4N5CCC(CC5)N)C=NC2=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CP 673451

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 8.35 20

制备储备液 for CP 673451

以下数据基于产品分子量 417.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 11.98 mL 59.88 mL 119.76 mL
1 mM 2.4 mL 11.98 mL 23.95 mL
2 mM 1.2 mL 5.99 mL 11.98 mL
10 mM 0.24 mL 1.2 mL 2.4 mL

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产品说明书 for CP 673451

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for CP 673451

参考文献是支持产品生物活性的出版物。

Roberts et al (2005) Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451. Cancer Res. 65 957 PMID: 15705896

If you know of a relevant reference for CP 673451, please let us know.

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关键词: CP 673451, CP 673451 supplier, CP673451, PDGFRβ, beta, inhibitors, inhibits, platelet, derived, growth, factor, receptor, potent, selective, PDGFR, 5993, Tocris Bioscience

1 篇 CP 673451 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CP 673451 的部分引用包括：

Stacey M et al (2021) A Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane. Cell Stem Cell 28 315-330.e5 PMID: 33181078

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.