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Submit ReviewCP 94253 hydrochloride
说明： Potent and selective 5-HT1B agonist
化学名： 5-Propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine hydrochloride
纯度： ≥98% (HPLC)
生物活性 for CP 94253 hydrochloride
CP 94253 hydrochloride is a potent, selective 5-HT1B agonist (Ki values are 89, 2, 860, 49 and 1,600 nM for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D and 5-HT2 receptors respectively). Centrally active upon systemic administration in vivo.
化合物库 for CP 94253 hydrochloride
CP 94253 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for CP 94253 hydrochloride
| 分子量 | 293.8 |
| 公式 | C15H19N3O.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 845861-39-4 |
| PubChem ID | 11652258 |
| InChI Key | PIIOXKQIZCVXMD-UHFFFAOYSA-N |
| Smiles | Cl.CCCOC1=CC=C2NC=C(C2=N1)C1=CCNCC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CP 94253 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 7.34 | 25 | |
| DMSO | 29.38 | 100 |
制备储备液 for CP 94253 hydrochloride
以下数据基于产品分子量 293.8。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.4 mL | 17.02 mL | 34.04 mL |
| 5 mM | 0.68 mL | 3.4 mL | 6.81 mL |
| 10 mM | 0.34 mL | 1.7 mL | 3.4 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
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产品说明书 for CP 94253 hydrochloride
参考文献 for CP 94253 hydrochloride
参考文献是支持产品生物活性的出版物。
Fish et al (1999) Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT(1B) receptor agonist CP-94,253. Psychopharmacology 146 391 PMID: 10550489
Knobelman et al (2000) Regulation of extracellular concentrations of 5-hydroxytryptamine (5-HT) in mouse striatum by 5-HT1A and 5-HT1B receptors. J.Pharmacol.Exp.Ther. 292 1111 PMID: 10688630
Koe et al (1992) Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Dev.Res. 26 241
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关键词: CP 94253 hydrochloride, CP 94253 hydrochloride supplier, Potent, selective, 5-HT1B, agonists, Serotonin, Receptors, CP94253, hydrochloride, 1317, Tocris Bioscience
7 篇 CP 94253 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CP 94253 hydrochloride 的部分引用包括：
Gadgaard & Jensen (2020) Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol 175 PMID: 32088264
Doslikova et al (2013) 5-HT2C receptor agonist anorectic efficacy potentiated by 5-HT1B receptor agonist coapplication: an effect mediated via increased proportion of pro-opiomelanocortin neurons activated. J Neurosci 33 9800 PMID: 23739976
Hagan et al (2012) 5-HT(1B) autoreceptor regulation of serotonin transporter activity in synaptosomes. Synapse 66 1024 PMID: 22961814
Mansari et al (2015) Effects of acute and sustained administration of Vort. on the serotonin system in the hippocampus: electrophysiological studies in the rat brain. Neuron 232 2343 PMID: 25665528
McDevitt et al (2011) Serotonin 1B autoreceptors originating in the caudal dorsal raphe nucleus reduce expression of fear and depression-like behavior. Pain 69 780 PMID: 21353664
Eriksson et al (2013) Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11. Psychopharmacology (Berl) 18 1096 PMID: 23032875
Heisler et al (2006) Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Biol Psychiatry 51 239 PMID: 16846858
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CP 94253 hydrochloride 的评论
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CP-94253 reduces food intake in obese mice.
By
Sergiy Sylantyev on 12/10/2023
分析类型： In Vivo
种属： Mouse
CP-94253 was used to test an impact of 5HT-1B receptor on feeding behaviour in mice. Illustration: CP-94253 (16 mg/kg i.p.) significantly decreased high fat diet intake in obese mice compared to saline treatment. Repeated measures ANOVA followed by Dunnett’s post hoc tests, * - P<0.05, ** - P<0.01.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
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