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CRANAD 2

Cat. No. 4803 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Near-infrared probe that detects Aβ40 aggregates. Used for: amyloid-β detection in vitro and in vivo. Application: fluorescence microscopy, epifluorescence microscopy
化学名： (T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CRANAD 2

Key information: CRANAD 2 is a curcumin derivatized near-infrared probe that binds to Aβ40 aggregates. Penetrates the blood-brain barrier.

Used for: amyloid- detection in vitro, tissue and in vivo. Shown to bind to plaques in APP-PS1 transgenic mice, in vitro. Detects senile plaques in 19-month-old Tg2576 mice in vivo.

Application: Fluorescence microscopy, epifluorescence microscopy.

Properties and Photophysical Data: CRANAD 2 binds to Aβ40 aggregates (Kd = 38 nM) and elicits upon interacting with Aβ aggregates, an emission blue shift (from 805 nm to 715 nm). When unbound in PBS, excitation and emission maxima (λ) are 640 nm and 805 nm, respectively.

技术数据 for CRANAD 2

分子量 410.26
公式 C23H25BF2N2O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1193447-34-5
PubChem ID 46861929
InChI Key GNLVJIICVWDSNI-LFYBBSHMSA-N
Smiles CN(C)C(C=C3)=CC=C3/C=C/C1=CC(/C=C/C2=CC=C(N(C)C)C=C2)=[O+][B-](F)(F)O1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CRANAD 2

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 2.05 5 温和加热

制备储备液 for CRANAD 2

以下数据基于产品分子量 410.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.05 mM 48.75 mL 243.75 mL 487.5 mL
0.25 mM 9.75 mL 48.75 mL 97.5 mL
0.5 mM 4.87 mL 24.37 mL 48.75 mL
2.5 mM 0.97 mL 4.87 mL 9.75 mL

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参考文献 for CRANAD 2

参考文献是支持产品生物活性的出版物。

Ran et al (2009) Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. J.Am.Chem.Soc. 131 15257 PMID: 19807070

Ran et al (2011) Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species. PLoS One. 6 e19362 PMID: 21559413

Ni et al (2021) In-vitro and in-vivo characterization of CRANAD-2 for multi-spectral optoacoustic tomography and fluorescence imaging of amyloid-beta deposits in Alzheimer mice. Photoacoustics 23 100285 PMID: 34354924

If you know of a relevant reference for CRANAD 2, please let us know.

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关键词: CRANAD 2, CRANAD 2 supplier, near-infrared, NIR, probes, AB40, AB, amyloid-beta, beta-amyloid, aggregates, senile, plaques, Tg2576, amyloidb, amyloidβ, Amyloid, Beta, Peptides, Fluorescent, B, Probes, 4803, Tocris Bioscience

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Fluorescent Dyes and Probes Research Product Guide

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