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Submit ReviewCRBN5-SNAP2-1C-PIP 最新
说明： SNAP-tag labeled fusion protein Degrader (PROTAC®)
化学名： N-(4-(((2-Amino-6-chloropyrimidin-4-yl)oxy)methyl)benzyl)-2-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)acetamide
纯度： ≥97% (HPLC)
生物活性 for CRBN5-SNAP2-1C-PIP
CRBN5-SNAP2-1C-PIP is a SNAP tag labeled fusion protein Degrader (PROTAC®; Dmax = 75% at 1 μM). CRBN5-SNAP2-1C-PIP recruits cereblon E3 ligase to induce the degradation of SNAP-fusion proteins..
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
技术数据 for CRBN5-SNAP2-1C-PIP
| 分子量 | 646.1 |
| 公式 | C32H32ClN7O6 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| InChI Key | HZTNPAVHBCQKFV-UHFFFAOYSA-N |
| Smiles | O=C(NCC1=CC=C(COC2=NC(N)=NC(Cl)=C2)C=C1)CC3CCN(C4=CC=C(C(N(C5CCC(NC5=O)=O)C6=O)=O)C6=C4)CC3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CRBN5-SNAP2-1C-PIP
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 64.61 | 100 |
制备储备液 for CRBN5-SNAP2-1C-PIP
以下数据基于产品分子量 646.1。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.55 mL | 7.74 mL | 15.48 mL |
| 5 mM | 0.31 mL | 1.55 mL | 3.1 mL |
| 10 mM | 0.15 mL | 0.77 mL | 1.55 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.31 mL |
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产品说明书 for CRBN5-SNAP2-1C-PIP
参考文献 for CRBN5-SNAP2-1C-PIP
参考文献是支持产品生物活性的出版物。
Pol et al (2024) Induced degradation of SNAP-fusion proteins. RSC Chem.Biol. 5 1232 PMID: 39444693
If you know of a relevant reference for CRBN5-SNAP2-1C-PIP, please let us know.
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关键词: CRBN5-SNAP2-1C-PIP, CRBN5-SNAP2-1C-PIP supplier, degrader, degraders, proteolysis, targeting, chimera, PROTAC, degradation, tpd, E3, ligase, cereblon, SNAP-tag, labeled, fusion, protein, Other, Degraders, 8891, Tocris Bioscience
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TPD and Induced Proximity Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Assays for Protein Degradation
- Induced Proximity Tools
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia