CRID3 sodium salt

Cat. No. 5479 10 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production

别名： CP-456773,MCC 950

化学名： N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt

纯度： ≥98% (HPLC)

引用文献 (10)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CRID3 sodium salt

CRID3 sodium salt is a potent NLRP3 inflammasome inhibitor; closes the active conformation of NLRP3 to the inactive state. Directly interacts with the Walker B motif within the NLRP3 NACHT domain. Inhibits IL-1β, IL-18 and IL-1α production (IC₅₀ values are 7.2, 10.3 and 12-18 nM, respectively). Selective for NLRP3 over NLRC4 inflammasome and Toll-like receptor signaling. Reduces severity of experimental autoimmune encephalomyelitis, skin inflammation and airway inflammation in mice. Also glutathione S-transferase omega 1 inhibitor. Orally bioavailable.

许可信息

Sold for research purposes under agreement from Pfizer Inc

技术数据 for CRID3 sodium salt

分子量	426.46
公式	C₂₀H₂₃N₂NaO₅S
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	256373-96-3
PubChem ID	91826093
InChI Key	LFQQNXFKPNZRFT-UHFFFAOYSA-M
Smiles	O=C(N(S(C4=CC(C(C)(O)C)=CO4)(=O)=O)[Na])NC1=C3C(CCC3)=CC2=C1CCC2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CRID3 sodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	42.65	100
	DMSO	42.65	100

制备储备液 for CRID3 sodium salt

以下数据基于产品分子量 426.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.34 mL	11.72 mL	23.45 mL
5 mM	0.47 mL	2.34 mL	4.69 mL
10 mM	0.23 mL	1.17 mL	2.34 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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产品说明书 for CRID3 sodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CRID3 sodium salt

参考文献是支持产品生物活性的出版物。

Laliberte et al (2003) Glutathione S-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1β posttranslational processing. J.Biol.Chem. 278 16567 PMID: 12624100

Coll et al (2015) A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat.Med. 21 248 PMID: 25686105

Gordon et al (2018) Inflammasome inhibition prevents a-synuclein pathology and dopaminergic neurodegeneration in mice. Sci.Transl.Med. 10 eaah4066 PMID: 30381407

Tapia-Abellán et al (2019) MCC950 closes the active conformation of NLRP3 to an inactive state. Nat.Chem.Biol. 15 560 PMID: 31086329

Coll et al (2019) MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition. Nat.Chem.Biol. 15 556 PMID: 31086327

If you know of a relevant reference for CRID3 sodium salt, please let us know.

按标靶查看相关产品

关键词: CRID3 sodium salt, CRID3 sodium salt supplier, CP456773, cytokine, release, inhibitory, drug, CRID3, Glutathione, S-transferase, omega, 1, GSTO1, inhibitors, inhibits, MCC950, nod-like, receptors, NLRP3, inflammasome, CP-456773, MCC, 950, Other, Transferases, Cytokines, Inflammasomes, 5479, Tocris Bioscience

10 篇 CRID3 sodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CRID3 sodium salt 的部分引用包括：

David A et al (2022) Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3. Proc Natl Acad Sci U S A 119 e2202577119 PMID: 36037361

Flóra et al (2022) Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1β pathway. Brain Behav Immun 101 318-332 PMID: 35065198

Goddard et al (2019) Enteropathogenic Escherichia coli Stimulates Effector-Driven Rapid Caspase-4 Activation in Human Macrophages. Cell Rep 27 1008 PMID: 31018119

Oliver T et al (2020) CARD8 inflammasome activation triggers pyroptosis in human T cells. EMBO J 39 e105071 PMID: 32840892

Minqi et al (2020) Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway. Drug Des Devel Ther 14 4901-4913 PMID: 33223823

Nagesh et al (2020) Inhibition of Amyloid-Beta Production, Associated Neuroinflammation, and Histone Deacetylase 2-Mediated Epigenetic Modifications Prevent Neuropathology in Alzheimer's Disease in vitro Model. Front Aging Neurosci 11 342 PMID: 32009938

Nitya et al (2020) Genetic and pharmacological inhibition of inflammasomes reduces the survival of Mycobacterium tuberculosis strains in macrophages. Sci Rep 10 3709 PMID: 32111888

Chauhan et al (2018) BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages. Cell Rep 25 2354 PMID: 30485805

Eduardo et al (2021) An in vitro study of ApxI from Actinobacillus pleuropneumoniae serotype 10 and induction of NLRP3 inflammasome-dependent cell death. Vet Rec Open 8 e20 PMID: 34631111

Catherine B et al (2021) Inhibition of the NLRP3 inflammasome by HSP90 inhibitors. Immunology 162 84-91 PMID: 32954500

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