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CS 2100

Cat. No. 4543 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective S1P1 agonist
化学名： 1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid
纯度： ≥97% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CS 2100

CS 2100 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 4.0 nM). Exhibits 5000-fold selectivity for human S1P1 over S1P3. Displays efficacy in a rat adjuvant-induced arthritis model.

技术数据 for CS 2100

分子量 461.53
公式 C25H23N3O4S
储存 Store at +4°C
纯度 ≥97% (HPLC)
CAS Number 913827-99-3
PubChem ID 11977938
InChI Key DWVJASHDNJMDNH-UHFFFAOYSA-N
Smiles CCC1=C(C2=NOC(C4=CC=C(OC5=CC=CC=C5)C=C4)=N2)SC(CN3CC(C(O)=O)C3)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CS 2100

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 2.31 5 温和加热

制备储备液 for CS 2100

以下数据基于产品分子量 461.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.05 mM 43.33 mL 216.67 mL 433.34 mL
0.25 mM 8.67 mL 43.33 mL 86.67 mL
0.5 mM 4.33 mL 21.67 mL 43.33 mL
2.5 mM 0.87 mL 4.33 mL 8.67 mL

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参考文献 for CS 2100

参考文献是支持产品生物活性的出版物。

Nakamura et al (2012) Synthesis and evaluation of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist. Eur.J.Med.Chem. 51 92 PMID: 22405291

Nakamura et al (2012) Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist. Bioorg.Med.Chem.Lett. 22 1788 PMID: 22264485

If you know of a relevant reference for CS 2100, please let us know.

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关键词: CS 2100, CS 2100 supplier, CS2100, sphingosine-1-phosphate, receptors, S1P1, selective, agonists, Sphingosine-1-phosphate, Receptors, 4543, Tocris Bioscience

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