CU CPT 4a

Cat. No. 4883 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective TLR3 inhibitor

化学名： N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine

纯度： ≥98% (HPLC)

引用文献 (2)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CU CPT 4a

CU CPT 4a is a selective TLR3 inhibitor (IC₅₀ = 3.44 μM in RAW 264.7 cells); suppresses downstream signaling pathways mediated by the TLR3/dsRNA complex, inhibiting TNF-α and IL-1β production in whole cells. Reduces death of crypt cells and improves gastrointestinal syndrome in mice.

许可信息

Sold under license from the University of Colorado

化合物库 for CU CPT 4a

CU CPT 4a is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for CU CPT 4a

分子量	377.82
公式	C₁₈H₁₃ClFNO₃S
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1279713-77-7
PubChem ID	53242268
InChI Key	IAASQMCXDRISAV-CYBMUJFWSA-N
Smiles	O=C(N[C@H](CC3=CC=CC=C3)[C@@](O)=O)C2=C(Cl)C1=CC=C(F)C=C1S2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CU CPT 4a

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	37.78	100

制备储备液 for CU CPT 4a

以下数据基于产品分子量 377.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.65 mL	13.23 mL	26.47 mL
5 mM	0.53 mL	2.65 mL	5.29 mL
10 mM	0.26 mL	1.32 mL	2.65 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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产品说明书 for CU CPT 4a

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CU CPT 4a

参考文献是支持产品生物活性的出版物。

Cheng et al (2011) Small-molecule inhibitors of the TLR3/dsRNA complex. J.Am.Chem.Soc. 133 3764 PMID: 21355588

Takemura et al (2014) Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat.Commun. 18 PMID: 24637670

If you know of a relevant reference for CU CPT 4a, please let us know.

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关键词: CU CPT 4a, CU CPT 4a supplier, CUCPT4a, toll, like, receptors, ligands, antagonists, TLR3, inflammation, TNF-, #945, TNF-1, TNF-alpha, IL-#946, IL-b, IL-beta, Toll-like, Receptors, 4883, Tocris Bioscience

2 篇 CU CPT 4a 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CU CPT 4a 的部分引用包括：

Gerhard et al (2020) Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis. JCI Insight 5 PMID: 32213712

Grigoryeva et al (2021) Human macrophages utilize a wide range of pathogen recognition receptors to recognize Legionella pneumophila, including Toll-Like Receptor 4 engaging Legionella lipopolysaccharide and the Toll-like Receptor 3 nucleic-acid sensor PLoS Pathog 17 e1009781 PMID: 34280250

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Pathways for CU CPT 4a

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.