主页 / 药理学 / Enzyme-Linked Receptors / Toll-like Receptors / Toll-like Receptor Inhibitors / CU CPT 9a

CU CPT 9a

Cat. No. 6479 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Highly potent TLR8 inhibitor
化学名： 2-Methyl-4-(7-methoxy-4-quinolinyl)phenol
纯度： ≥98% (HPLC)
说明书
引用文献
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CU CPT 9a

CU CPT 9a is a potent TLR8 inhibitor (IC50 = 0.5 nM and Kd = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.

许可信息

Sold under license from the University of Colorado

化合物库 for CU CPT 9a

CU CPT 9a is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for CU CPT 9a

分子量 265.31
公式 C17H15NO2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2165340-32-7
PubChem ID 135567383
InChI Key HNYBTVKYLVLWCB-UHFFFAOYSA-N
Smiles COC1=CC2=C(C(C3=CC(C)=C(C=C3)O)=CC=N2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CU CPT 9a

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 26.53 100
ethanol 5.31 20

制备储备液 for CU CPT 9a

以下数据基于产品分子量 265.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.77 mL 18.85 mL 37.69 mL
5 mM 0.75 mL 3.77 mL 7.54 mL
10 mM 0.38 mL 1.88 mL 3.77 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for CU CPT 9a

参考文献是支持产品生物活性的出版物。

Zhang et al (2018) Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat.Chem.Biol. 14 58 PMID: 29155428

If you know of a relevant reference for CU CPT 9a, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Toll-like Receptor Inhibitors

关键词: CU CPT 9a, CU CPT 9a supplier, CUCPT9a, toll-like, receptors, TLR8, inhibitors,, inhibits, potent, Toll-like, Receptors, 6479, Tocris Bioscience

篇 CU CPT 9a 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 CU CPT 9a 的引用文献。 您是否知道使用了 Tocris CU CPT 9a 的优秀论文？ 请告知我们.

CU CPT 9a 的评论

目前没有该产品的评论。 Be the first to review CU CPT 9a and earn rewards!

Have you used CU CPT 9a?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Pathways for CU CPT 9a

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.