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CU-T12-9

Cat. No. 5414 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent TLR1/2 agonist
化学名： N-Methyl-4-nitro-2-(4-(4-trifluoromethyl)phenyl)-1H-imidazol-1-yl)aniline
纯度： ≥99% (HPLC)
说明书
引用文献
评论 (1)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CU-T12-9

CU-T12-9 is a potent TLR1/2 agonist (EC50 = 52.9 nM). Activates the NF-κB pathway and upregulates proinflammatory cytokines in vitro. Also enhances TLR1 and TLR2 dimerization.

许可信息

Sold under license from the University of Colorado

化合物库 for CU-T12-9

CU-T12-9 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for CU-T12-9

分子量 362.31
公式 C17H13F3N4O2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1821387-73-8
PubChem ID 91826088
InChI Key LITXVDAFEYLWQE-UHFFFAOYSA-N
Smiles CNC1=CC=C([N+]([O-])=O)C=C1N2C=C(C3=CC=C(C(F)(F)F)C=C3)N=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CU-T12-9

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.23 100
ethanol 7.25 20

制备储备液 for CU-T12-9

以下数据基于产品分子量 362.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.8 mL 27.6 mL
5 mM 0.55 mL 2.76 mL 5.52 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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参考文献 for CU-T12-9

参考文献是支持产品生物活性的出版物。

Cheng et al (2013) Discovery of small molecule inhibitors of the TLR1-TLR2 complex. Angew.Chem.Int.Ed.Engl. 51 12246 PMID: 22969053

Cheng et al (2015) Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists Sci.Adv. 1 e1400139 PMID: 26101787

If you know of a relevant reference for CU-T12-9, please let us know.

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关键词: CU-T12-9, CU-T12-9 supplier, Potent, TLR1/2, activators, activates, Toll-like, Receptors, 5414, Tocris Bioscience

篇 CU-T12-9 的引用文献

引用文献是使用了 Tocris 产品的出版物。

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CU-T12-9 的评论

平均评分: 5 (Based on 1 Review.)

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activation of NF-kappa B pathway in presence of CUt-12-9.
By Tahmineh Safaie on 02/28/2020
分析类型： In Vitro
种属： Mouse
细胞系/组织： Raw-Blue

Raw-Blue cell lines were treated with different concentration of CU-T129 for 24 hours and the level of Seap was measured

review image

Pathways for CU-T12-9

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.