Cyclic Pifithrin-α hydrobromide

Cat. No. 3843 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： p53 inhibitor

别名： Pifithrin-β

化学名： 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole hydrobromide

纯度： ≥98% (HPLC)

引用文献 (2)

文献 (2)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Cyclic Pifithrin-α hydrobromide

Cyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes (EC₅₀ = 2.01 μM). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents.

化合物库 for Cyclic Pifithrin-α hydrobromide

Cyclic Pifithrin-a hydrobromide is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Cyclic Pifithrin-α hydrobromide

分子量	349.29
公式	C₁₆H₁₆N₂S.HBr
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	511296-88-1
PubChem ID	11515812
InChI Key	SGNCOAOESGSEOP-UHFFFAOYSA-N
Smiles	CC(C=C4)=CC=C4C1=CN(C2=C(S3)CCCC2)C3=N1.Br

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cyclic Pifithrin-α hydrobromide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	34.93	100

制备储备液 for Cyclic Pifithrin-α hydrobromide

以下数据基于产品分子量 349.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.86 mL	14.31 mL	28.63 mL
5 mM	0.57 mL	2.86 mL	5.73 mL
10 mM	0.29 mL	1.43 mL	2.86 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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产品说明书 for Cyclic Pifithrin-α hydrobromide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Cyclic Pifithrin-α hydrobromide

参考文献是支持产品生物活性的出版物。

Barchechath et al (2005) Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-α. J.Med.Chem. 48 6409 PMID: 16190767

Pietrancosta et al (2005) Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies. Bioorg.Med.Chem.Lett. 15 1561 PMID: 15745797

Zuco and Zunino (2008) Cyclic Pifithrin-α sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis. Neoplasia 10 587 PMID: 18516295

If you know of a relevant reference for Cyclic Pifithrin-α hydrobromide, please let us know.

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关键词: Cyclic Pifithrin-a hydrobromide, Cyclic Pifithrin-a hydrobromide supplier, inhibits, inhibitors, p53, apoptosis, Cyclic, Pifithrin-alpha, hydrobromide, Pifithrin-a, Pifithrin-α, Pifithrin-b, Pifithrin-beta, Pifithrin-β, 3843, Tocris Bioscience

2 篇 Cyclic Pifithrin-α hydrobromide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Cyclic Pifithrin-α hydrobromide 的部分引用包括：

F et al (2015) The p53 co-activator Zac1 neither induces cell cycle arrest nor apoptosis in chicken Lim1 horizontal progenitor cells. Cell Death Discov 1 15023 PMID: 27551456

Benkafadar et al (2017) Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy. EMBO Mol Med 9 7 PMID: 27794029

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Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for Cyclic Pifithrin-α hydrobromide

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.