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CYM 50308

Cat. No. 4678 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective S1P4 agonist
化学名： (2Z,5Z)-5-[[1-(2,4-Difluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]methylene]-2-[(2-methoxyethyl)imino]-3-methyl-4-thiazolidinone
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CYM 50308

CYM 50308 is a potent and selective sphingosine-1-phosphate receptor 4 (S1P4) agonist (EC50 values are 56 nM and 2100 nM for S1P4 and S1P5 receptors, respectively). Displays no activity at S1P1, S1P2 and S1P3 receptors at concentrations up to 25 μM.

技术数据 for CYM 50308

分子量 405.46
公式 C20H21F2N3O2S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1345858-76-5
PubChem ID 49835928
InChI Key BKQZKTRCUAWRHT-ONBPWHQPSA-N
Smiles FC1=CC(F)=C(N2C(C)=CC(/C=C3\S/C(N(C)C3=O)=N\CCOC)=C2C)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CYM 50308

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 4.05 10

制备储备液 for CYM 50308

以下数据基于产品分子量 405.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 24.66 mL 123.32 mL 246.63 mL
0.5 mM 4.93 mL 24.66 mL 49.33 mL
1 mM 2.47 mL 12.33 mL 24.66 mL
5 mM 0.49 mL 2.47 mL 4.93 mL

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参考文献 for CYM 50308

参考文献是支持产品生物活性的出版物。

Urbano et al (2011) Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype. Bioorg.Med.Chem.Lett. 21 6739 PMID: 21982495

If you know of a relevant reference for CYM 50308, please let us know.

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关键词: CYM 50308, CYM 50308 supplier, CYM50308, sphingosine-1-phosphate, receptors, S1P4, agonists, potent, selective, Sphingosine-1-phosphate, Receptors, 4678, Tocris Bioscience

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