CYM 50358 hydrochloride

Cat. No. 4679 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent and selective S1P₄ antagonist

化学名： N-[(4-(Aminomethyl)-2,6-dimethylphenyl]-5-(2,5-dichlorophenyl)-2-furancarboxamide hydrochloride

纯度： ≥97% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CYM 50358 hydrochloride

CYM 50358 hydrochloride is a potent S1P₄ antagonist (IC₅₀ = 25 nM). Displays selectivity for S1P₄ against S1P₁, S1P₂, S1P₃ and S1P₅ receptors.

技术数据 for CYM 50358 hydrochloride

分子量	425.74
公式	C₂₀H₁₈Cl₂N₂O₂.HCl
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	1781750-72-8
PubChem ID	78243726
InChI Key	OFDSTJOMVDAKCS-UHFFFAOYSA-N
Smiles	O=C(NC3=C(C)C=C(CN)C=C3C)C1=CC=C(C2=C(Cl)C=CC(Cl)=C2)O1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CYM 50358 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	42.57	100
	DMSO	42.57	100

制备储备液 for CYM 50358 hydrochloride

以下数据基于产品分子量 425.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.35 mL	11.74 mL	23.49 mL
5 mM	0.47 mL	2.35 mL	4.7 mL
10 mM	0.23 mL	1.17 mL	2.35 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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产品说明书 for CYM 50358 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CYM 50358 hydrochloride

参考文献是支持产品生物活性的出版物。

Guerrero et al (2011) Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P₄) receptor antagonists. Bioorg.Med.Chem.Lett. 21 3632 PMID: 21570287

Cencetti et al (2013) TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation. FASEB J. 27 4532 PMID: 23913862

If you know of a relevant reference for CYM 50358 hydrochloride, please let us know.

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Sphingosine-1-Phosphate Receptors

关键词: CYM 50358 hydrochloride, CYM 50358 hydrochloride supplier, CYM50358, hydrochloride, sphingosine-1-phosphate, receptors, S1P, S1P4, antagonists, potent, selective, Sphingosine-1-phosphate, Receptors, 4679, Tocris Bioscience

2 篇 CYM 50358 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CYM 50358 hydrochloride 的部分引用包括：

Richard M et al (2022) Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation. Immunity 55 254-271.e7 PMID: 35139352

Chen et al (2023) Inhibition of sphingosine-1-phosphate receptor 3 suppresses ATP-induced NLRP3 inflammasome activation in macrophages via TWIK2-mediated potassium efflux. Front Immunol 14 1090202 PMID: 36798132

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