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CYM 5520

Cat. No. 5418 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective S1P2 allosteric agonist
化学名： 1-[2-[2,5-Dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-1,6-dihydro-6-oxo-3-pyridinecarbonitrile
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CYM 5520

CYM 5520 is a selective S1P2 allosteric agonist (EC50 = 0.48 μM). Selective for S1P2 receptors over a panel of 29 other receptors and transporters.

技术数据 for CYM 5520

分子量 345.39
公式 C21H19N3O2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1449747-00-5
PubChem ID 25110470
InChI Key FMYGNANMYYHBSU-UHFFFAOYSA-N
Smiles CC1=C(C(CN3C=C(C#N)C=CC3=O)=O)C=C(C)N1CC2=CC=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CYM 5520

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 34.54 100

制备储备液 for CYM 5520

以下数据基于产品分子量 345.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.9 mL 14.48 mL 28.95 mL
5 mM 0.58 mL 2.9 mL 5.79 mL
10 mM 0.29 mL 1.45 mL 2.9 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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参考文献 for CYM 5520

参考文献是支持产品生物活性的出版物。

Satsu et al (2013) A sphingosine 1-phosphate receptor 2 selective allosteric agonist. Bioorg.Med.Chem. 21 5373 PMID: 23849205

If you know of a relevant reference for CYM 5520, please let us know.

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关键词: CYM 5520, CYM 5520 supplier, selective, allosteric, agonists, sphingosine-1-phosphate, receptor, 2, S1P2, S1PR2, agonism, CYM5520, Sphingosine-1-phosphate, Receptors, 5418, Tocris Bioscience

2 篇 CYM 5520 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CYM 5520 的部分引用包括：

Balaji M et al (2021) Two distinct trophectoderm lineage stem cells from human pluripotent stem cells. J Biol Chem 296 100386 PMID: 33556374

Matsushima-Nishiwaki et al (2018) Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2. PLoS One 13 e0209050 PMID: 30543684

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