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Submit ReviewCytochalasin D
说明： Disrupts actin filament function
别名： Zygosporin A
化学名： (7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione
纯度： ≥95% (HPLC)
生物活性 for Cytochalasin D
Cytochalasin D is a potent disruptor of actin filament function. Alters tight junction permeability. Unlike cytochalasin B (Cat. No. 5474), does not inhibit monosaccharide transport across the plasma membrane.
技术数据 for Cytochalasin D
| 分子量 | 507.63 |
| 公式 | C30H37NO6 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 22144-77-0 |
| PubChem ID | 98137101 |
| InChI Key | SDZRWUKZFQQKKV-HYKYWQBKSA-N |
| Smiles | C=C([C@H]4C)[C@@H](O)[C@]([C@@]1([C@H](OC(C)=O)/C=C/[C@@](O)3C)[C@]4([H])[C@@H](CC2=CC=CC=C2)N[C@]1=O)([H])/C=C/C[C@H](C)C3=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Cytochalasin D
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 5 | 10 温和加热 | |
| DMSO | 25 | 50 |
制备储备液 for Cytochalasin D
以下数据基于产品分子量 507.63。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.94 mL | 19.7 mL | 39.4 mL |
| 2.5 mM | 0.79 mL | 3.94 mL | 7.88 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.94 mL |
| 25 mM | 0.08 mL | 0.39 mL | 0.79 mL |
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产品说明书 for Cytochalasin D
参考文献 for Cytochalasin D
参考文献是支持产品生物活性的出版物。
Abedi and Zachary (1998) Cytochalasin D stimulation of tyrosine phosphorylation and phosphotyrosine-associated kinase activity in vascular smooth muscle cells. Biochem.Biophys.Res.Commun. 245 646 PMID: 9588169
Carlier et al (1986) Interaction of cytochalasin D with actin filaments in the presence of ADP and ATP. J.Biol.Chem. 261 2041 PMID: 3944126
Stevenson and Begg (1994) Concentration-dependent effects of cytochalasin D on tight junctions and actin filaments in MDCK epithelial cells. J.Cell Sci. 107 367 PMID: 8006058
If you know of a relevant reference for Cytochalasin D, please let us know.
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关键词: Cytochalasin D, Cytochalasin D supplier, Disrupts, actin, filament, function, CytochalasinD, ZygosporinA, Zygosporin, A, Actin, 1233, Tocris Bioscience
21 篇 Cytochalasin D 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Cytochalasin D 的部分引用包括：
Lee et al (2019) Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments. Nat Commun 10 529 PMID: 30705265
Diaz-Garcia et al (2017) Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake. Cell Metab 26 361 PMID: 28768175
Lahne et al (2015) Actin-Cytoskeleton- and Rock-Mediated INM Are Required for Photoreceptor Regeneration in the Adult Zebrafish Retina. J Neurosci 35 15612 PMID: 26609156
Gaume et al (2015) Centrosomal nucleolin is required for microtubule network organization. Cell Cycle 14 902 PMID: 25590348
Nakamura et al (2013) Raman spectroscopic imaging of the whole Ciona intestinalis embryo during development. PLoS One 8 e71739 PMID: 23977129
Weidert et al (2014) Actinomyosin contraction, phosphorylation of VE-cadherin, and actin remodeling enable melanoma-induced endothelial cell-cell junction disassembly. PLoS One 9 e108092 PMID: 25225982
Subramanian et al (2012) Signaling through L-selectin mediates enhanced chemotaxis of lymphocyte subsets to secondary lymphoid tissue chemokine. J Immunol 188 3223 PMID: 22387549
Fernandez et al (2012) Mitotic spindle orients perpendicular to the forces imposed by dynamic shear. PLoS One 6 e28965 PMID: 22220200
Bose and Thomas (2009) The actin cytoskeleton differentially regulates NG115-401L cell ryanodine receptor and inositol 1,4,5-trisphosphate receptor induced calcium signaling pathways. Int J Mol Sci 379 594 PMID: 19126405
Gault et al (2014) Osmotic surveillance mediates rapid wound closure through nucleotide release. J Cell Biol 207 767 PMID: 25533845
Gjorevski and Nelson (2010) Endogenous patterns of mechanical stress are required for branching morphogenesis. Biochem Biophys Res Commun 2 424 PMID: 20717570
Lee et al (2014) Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. Cell Death Dis 111 E5114 PMID: 25385580
Mora et al (2013) Recombinant probes reveal dynamic localization of CaMKIIα within somata of cortical neurons. J Neurosci 33 14579 PMID: 24005308
Jeyaraj et al (2012) Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells. Integr Biol (Camb) 303 C499 PMID: 22621783
Lin et al (2012) Curcumin inhibits glutamate release from rat prefrontal nerve endings by affecting vesicle mobilization. PLoS One 13 9097 PMID: 22942754
Gomez et al (2010) Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction. Dis Model Mech 110 44 PMID: 20336666
Chen et al (2015) G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases. Elife 4 PMID: 25774600
Chambers et al (2015) Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation. Elife 4 PMID: 25774599
Lopez-Escobar et al (2015) The effect of maternal diabetes on the Wnt-PCP pathway during embryogenesis as reflected in the developing mouse eye. Proc Natl Acad Sci U S A 8 157 PMID: 25540130
Yang et al (2015) ICAM-1 suppresses tumor metastasis by inhibiting macrophage M2 polarization through blockade of efferocytosis. Am J Physiol Cell Physiol 6 e1780 PMID: 26068788
Dobson et al (2015) Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling. Elife 10 e0125974 PMID: 25933382
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Cytochalasin D.
By
Clara Lubeseder-Martellato on 11/12/2021
分析类型： Ex Vivo
种属： Mouse
It was used as an inhibitor in cell culture and in 3-dimensional cultures.Concentrations tested from 1 uM to 10 uM for 48n hours for 2D cultures and 4 days for 3D cultures
