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Submit ReviewD-64131
说明： Tubulin polymerization inhibitor. Antitumor in vivo
化学名： (5-Methoxy-1H-indol-2-yl)phenylmethanone
纯度： ≥99% (HPLC)
生物活性 for D-64131
D-64131 is a novel inhibitor of tubulin polymerization; cytotoxic and inhibits tumor cell proliferation in vitro (IC50 = 74 nM). Prevents growth of tumor models in mice following oral administration in vivo.
技术数据 for D-64131
| 分子量 | 251.28 |
| 公式 | C16H13NO2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 74588-78-6 |
| PubChem ID | 3921152 |
| InChI Key | ICMIJSRDISNKOC-UHFFFAOYSA-N |
| Smiles | COC1=CC=C2NC(=CC2=C1)C(=O)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for D-64131
参考文献 for D-64131
参考文献是支持产品生物活性的出版物。
Beckers et al (2002) 2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Res. 62 3113 PMID: 12036922
Mahboobi et al (2001) Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents. J.Med.Chem. 44 4535 PMID: 11741473
关键词: D-64131, D-64131 supplier, inhibitors, inhibits, tubulin, polymerization, Antitumor, Tau, Microtubules, Mitosis, 1643, Tocris Bioscience
D-64131 的评论
平均评分: 5 (Based on 1 Review.)
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The antitumoral efficacy of D-64131 in comparison to paclitaxel and vincristine.
By
Anonymous on 12/23/2019
种属： Human
The antitumoral efficacy of D-64131 in comparison to paclitaxel and vincristine was evaluated in resistance mediated by the MRP and in human tumor cells with resistance to cisplatin, the topoisomerase I inhibitor SN-38 (7-ethyl-10-hydroxycamptothecin) and the thymidylate synthase inhibitors 5-fluorouracil and raltitexed.
该领域的文献
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets